지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Major depressive disorder is characterized by cellular and molecular alterations resulting in the depressive behavioral phenotypes. Preclinical and clinical studies have demonstrated the deficits, including cell atrophy and loss, in limbic and cortical regions of patients with depression, which is restored with antidepressants by reestablishing proper molecular changes. These findings have implicated the involvement of relevant intracellular signaling pathways in the pathogenetic and therapeutic mechanisms of depressive disorders. This review summarizes the current knowledge of the signal transduction mechanisms related to depressive disorders, including cyclic-AMP, mitogen-activated protein kinase, Akt, and protein translation initiation signaling cascades. Understanding molecular components of signaling pathways regulating neurobiology of depressive disorders may provide the novel targets for the development of more efficacious treatment modalities.
목차
등록된 정보가 없습니다.
참고문헌 (94)
참고문헌 신청
Wong ML / 2004 / From monoamines to genomic targets: a paradigm shift for drug discovery in depression / Nat Rev Drug Discov 3:136~151
Diazgranados N / 2010 / A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression / Arch Gen Psychiatry 67:793~802
DiazGranados N / 2010 / Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder / J Clin Psychiatry 71:1605~1611
Li N / 2010 / mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists / Science 329:959~964
Autry AE / 2011 / NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses / Nature 475:91~95
Diazgranados N / 2010 / A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression / Arch Gen Psychiatry 67:793~802
DiazGranados N / 2010 / Rapid resolution of suicidal ideation after a single infusion of an N-methyl-D-aspartate antagonist in patients with treatment-resistant major depressive disorder / J Clin Psychiatry 71:1605~1611
Li N / 2010 / mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists / Science 329:959~964
Autry AE / 2011 / NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses / Nature 475:91~95
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