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논문 기본 정보

자료유형
학술저널
저자정보
유현주 (용인정신병원 정신건강의학과) 이유상 (용인정신병원 정신건강의학과) 안은숙 (용인정신병원 정신건강의학과) 정동화 (한국과학기술원 바이오및뇌공학과) 김성균 (한국과학기술원 바이오및뇌공학과) 정재승 (한국과학기술원 바이오및뇌공학과) 곽용태 (효자병원 신경과) 이승연 (세종대학교 응용통계학과)
저널정보
대한생물정신의학회 생물정신의학 생물정신의학 제22권 제4호
발행연도
2015.1
수록면
205 - 215 (11page)

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Objectives Sex hormones exposure during the prenatal period has an effect on cerebral lateralization. Male brains are thought to be more lateralized than female brains. Bipolar disorder was known to show abnormalities in cerebral laterality whose characteristics could be estimated by electroencephalography (EEG) coherences. We studied sex-related differences of EEG coherences between healthy controls and patients with bipolar disorder to examine the sex effects in the genesis of bipolar disorder. Methods Participants were 25 patients with bipolar disorder (11 male, 14 female) and 46 healthy controls (23 male, 23 female). EEG was recorded in the eyes closed resting state. To examine dominant EEG coherence associated with sex differences in both groups within five frequency bands (delta, theta, alpha, beta, and gamma) across several brain regions, statistical analyses were performed using analysis of covariance. Results Though statistically meaningful results were not found, some remarkable findings were noted. Healthy control females showed more increased interhemispheric coherences than control males in gamma frequency band. There were no differences in the intrahemispheric coherences between the healthy control males and females. In patients with bipolar disorder, female dominant pattern in interhemispheric coherences was attenuated compared with healthy control. Conclusions Sex differences of EEG coherences, which could be a marker for cerebral laterality, were attenuated in patients with bipolar disorder compared with healthy controls. These results imply that abnormal sex hormone exposure during early development might play some role in the pathogenesis of bipolar disorder.

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