지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 101 - 108 (8page)
이용수
초록· 키워드
오류제보하기
This study is conducted to investigate vasorelaxant effect of Corni Fructus(CF) on rabbit carotid artery. To determine vasorelaxant effect of CF on rabbit carotid artery, arterial sections with intact or removed endothelium were used in this organ bath study. After being contracted by phenylephrine(PE), arterial sections were treated with CF extract in a dose-dependent manner. To identity its mechanism, the contracted arterial sections by PE were pretreated with indomethacin(IM), tetraethylammonium chloride(TEA), Nω-nitro-L-arginine(L-NNA) or methylene blue(MB) and 1.0 ㎎/㎖ CF extract. We also studied to confirm the effect on influx of extracellular calcium chloride(Ca<sup>2+</sup>) of the CF extract in rabbit carotid artery. To measure the cytotoxicity of the CF extract, cell viability of human umbilical vein endothelial cell(HUVEC) was measured by MTT assay. Generation of nitric oxide(NO) was also measured by Griess reagent. The arterial sections with intact endothelium were relaxed significantly by CF extract, but this effect was inhibited in the arterial sections with damaged endothelium. The vasorelaxant effect was inhibited significantly when arterial sections were pretreated with IM, TEA, L-NNA, MB. In Ca<sup>2+</sup>-free krebs solution, increasing of arterial contraction by Ca<sup>2+</sup> was also inhibited by CF significantly. The treatment of CF extract increased NO concentration in HUVEC. This study suggested that the vasorelaxant effect of CF extract would be related with endothelium derived relaxing factor(EDRF) such as NO, prostacyclin(PGI<sub>2</sub>), endothelium derived hyperpolarization factor(EDHF).
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
산수유의 혈관이완효과 기전에 대한 연구
동의생리병리학회지
2016 .04
-
음경해면체에 미치는 山茱萸 물 추출물의 이완효과
동의생리병리학회지
2017 .12
-
The effect of cornus fructus on prostate in the andropause in vivo model
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Mixture of Corni Fructus and Schisandrae Fructus ameliorates testosterone-induced benign prostatic hyperplasia through regulating 5α-reductase 2 and androgen receptor
한국실험동물학회 학술발표대회 논문집
2022 .07
-
음경해면체에 미치는 산수유(山茱萸) 물 추출물의 이완효과
동의생리병리학회지
2017 .01
-
산수유의 최종당화산물 억제로 인한 주름 개선효과
대한본초학회지(본초분과학회지)
2017 .01
-
황기, 작약 및 산수유의 독성평가를 위한 성분분석 및 안정성 시험
생약학회지(Korean Journal of Pharmacognosy)
2017 .09
-
쇄양(鎖陽)의 내피세포 의존성 혈관이완효과
대한본초학회지(본초분과학회지)
2015 .01
-
산수유 추출물 및 분획물의 항산화 활성과 활성성분 분석
생약학회지(Korean Journal of Pharmacognosy)
2017 .09
-
마자인(麻子仁)이 치매병태모델의 운동과 인지기능에 미치는 실험적 연구
한방재활의학과학회지
2015 .01
-
The relaxing effect of poncirus fructus and its flavonoid content on porcine coronary artery
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Fructus Corni Officinalis water extract Ameliorates Memory Impairment and Beta amyloid (Aβ) clearance by LRP-1 Expression in the Hippocampus of a Rat model of Alzheimer’s Disease
동의생리병리학회지
2016 .01
-
Chrysanthemi Zawadskii Herba induced vasorelaxation mediated by endothelium-independent mechanisms in isolated rat thoracic aorta
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Treatment Results After Carotid Endarterectomy or Carotid Artery Stenting for Patients with Radiation-induced Carotid Stenosis
대한외과학회 학술대회 초록집
2021 .11
-
MIA로 유발된 골관절염 동물모델에서 산수유 추출물의 골관절염 개선 효과
대한한방내과학회지
2020 .01
-
Carotid artery stenting
Korean Circulation Journal
2018 .01
-
益智仁의 음경해면체 평활근 이완효과
대한본초학회지(본초분과학회지)
2015 .01
-
Anti-Proliferative Properties of Cornus mass Fruit in Different Human Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
도꼬마리 열매 복용으로 발생한 中毒症狀의 한방치료 1례
대한한방내과학회지
2015 .01
-
Vasorelaxant effects of commonly used traditional herbal prescriptions on isolated rat aortic rings
한국실험동물학회 학술발표대회 논문집
2020 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0