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Objectives: Alcoholic fatty liver is a potentially pathologic condition which can progress to steatohepatitis, fibrosis, and cirrhosis. The objective of this study is to investigate the effects of Scutellaria Radix (SR) extract on the alcoholic fatty liver induced by long-term EtOH administration. Results: Male Sprague Dawley rats were used in this study. All animals were randomly divided into Normal group, treated with saline (n=10); EtOH group, treated with ethanol (n=10); EtOH+SR group, treated with ethanol+Scutellaria Radix extract (n=10). For oral administration of ethanol in EtOH and EtOH+SR group, the ethanol was dissolved in distilled water in concentrations of 25% (v/v). Throughout the experiment of 8 week, the rats were allowed free access to water and standard chow. Sample group were administrated by Scutellaria Radix extract daily for 8 weeks. Results: The levels of hepatic marker such as aspartate aminotransferase and alanine aminotransferase were altered. Histopathological changes such as ballooning, fatty and hydropic degeneration were reduced and the expression of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) was significantly attenuated by Scutellaria Radix extract. Conclusions: These data suggest that Scutellaria Radix extract attenuated the alcoholic simple fatty liver by improving hepatic lipid metabolism via suppression of $TNF-{\alpha}$ protein. Scutellaria Radix could be effective in protecting the liver from alcoholic fatty liver.
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참고문헌 (26)
참고문헌 신청
Mezey E / 1980 / Alcoholic liver disease: roles of alcohol and malnutrition / Am J Clin Nutr 33(12):2709~2718
Lieber CS / 2000 / Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases / Mt Sinai J Med 67(1):84~94
Willner IR / 2005 / Alcohol and the liver / Curr Opin Gastroenterol 21(3):323~330
Nagata K / 2007 / Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis / J Toxicol Sci 32(5):453~468
Nagy LE / 2015 / The role of innate immunity in alcoholic liver disease / Alcohol Res 37(2):237~250
Lieber CS / 2000 / Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases / Mt Sinai J Med 67(1):84~94
Willner IR / 2005 / Alcohol and the liver / Curr Opin Gastroenterol 21(3):323~330
Nagata K / 2007 / Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis / J Toxicol Sci 32(5):453~468
Nagy LE / 2015 / The role of innate immunity in alcoholic liver disease / Alcohol Res 37(2):237~250
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