지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 315 - 320 (6page)
이용수
초록· 키워드
오류제보하기
This study investigated the signaling mechanisms contributed to the vasodilatory effects of HMC05, a herbal prescription. HMC05 acted in an endothelium-independent manner. To elucidate the fundamental mechanisms of its vascular actions, we focused on the signaling molecules involved in actin-myosin filament regulation including 20 kDa myosin light chains (LC20), Rho-associated kinase (ROCK), PKC, JNK and extracellular signal-regulated protein kinase (ERK) in the endothelium-denuded thoracic aorta or isolated smooth muscle cells (SMCs). It lowered the phosphorylation level of LC20 and showed that ROCK, ERK, JNK and $PKC{\alpha}$ pathways played important roles in the effects, as confirmed by the observations with a specific inhibition or activation, and with the activity and the subcellular localization of these molecules. In particular, HMC05 dramatically inhibited the activity of ERK and the downstream signaling of ROCK. It also changed the subcellular localization of the phophorylated $PKC{\alpha}$ as well as the amount of phosphorylation. Taken together, these data indicate that the vascular relaxation effects of HMC05 are attributed to the regulation of these signaling mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
HMC05의 혈관이완 활성과 신호전달 작용기전
동의생리병리학회지
2008 .04
-
HMC05의 휜쥐를 이용한 단회경구투여 독성시험
동의생리병리학회지
2008 .01
-
Effects of PCBs on human mast cell line HMC-1
대한약학회 학술대회
2000 .01
-
HMC05의 배양 Chinese Hamster Lung 세포를 이용한 염색체이상 시험
대한본초학회지(본초분과학회지)
2010 .01
-
HMO05의 Sprague - Dawley 흰쥐를 이용한 4주 반복 경구투여 DRF 독성시험
대한한의학회지
2009 .09
-
Typha orientalis inhibits inflammatory cytokine expression through suppression of ERK phosphorylation in HMC-1 cells
Oriental pharmacy and experimental medicine
2010 .01
-
HMC05의 경구투여 소핵시험 및 복귀돌연변이 시험
대한본초학회지(본초분과학회지)
2010 .01
-
柴胡가 HMC 및 Mouse의 염증관련 cytokine 분비에 미치는 영향
동의생리병리학회지
2009 .02
-
Effect of Korean folk medicine 'SecSec' on inflammatory cytokine secretion in HMC-1 cells
Oriental pharmacy and experimental medicine
2005 .01
-
Potential drug targets in the GPCR-$G{\alpha}_{12}/G{\alpha}_{13}$ signaling pathways
한국응용약물학회 춘계학술발표논문집
2008 .01
-
Panax Ginseng inhibited HIF-1a activation and inflammatory cytokine in HMC-1 cells activated by phorbol myristate acetate and A23187
Oriental pharmacy and experimental medicine
2008 .01
-
Emerging Co-signaling Networks in T Cell Immune Regulation
Immune Network
2013 .10
-
Evaluation of co-culture model with A549, THP-1, HMC-1 as an in vitro Air-liquid interface alveolar toxicity test model
환경독성보건학회 심포지엄 및 학술대회
2014 .11
-
The Inhibitory Effects of Lactose-β-sitosterol on the Inflammatory Responses of HMC-1 Cells and EoL-1 Cells
대한의생명과학회지
2011 .09
-
율피추출물의 사람 비만세포주 사이토카인 발현 억제 효과
대한본초학회지(본초분과학회지)
2013 .01
-
Endothelium Independent Effect of Pelargonidin on Vasoconstriction in Rat Aorta
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Hydrogen Peroxide Activates ERK in Cultured Feline Ileal Smooth Muscle Cells
대한약학회 학술대회
2002 .01
-
Anti-inflammatory effect of Samultang in human mast cell line HMC-1
Oriental pharmacy and experimental medicine
2006 .01
-
Regulatory Effect of Inflammatory Reaction by Asiasari Radix
동의생리병리학회지
2005 .01
-
Resveratrol Affects Protein Kinase C Activity and Promotes Apoptosis in Human Colon Carcinoma Cells
Asian Pacific journal of cancer prevention : APJCP
2012 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0