Eugenia jambolana seed extract supplementation attenuates cardiac and hepatic oxidative stress and pathophysiological changes in hypercholesterolemic rats

Sankhari, Jayanta M.; Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh V.; Ramachandran, A.V.

추천

검색

자료유형: 학술저널

저자정보: Sankhari, Jayanta M. (Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda) Jadeja, Ravirajsinh N. (Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda) Thounaojam, Menaka C. (Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda) Devkar, Ranjitsinh V. (Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda) Ramachandran, A.V. (Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, Faculty of Science, The M. S. University of Baroda)

저널정보: 경희한의학연구센터 Oriental pharmacy and experimental medicine Oriental pharmacy and experimental medicine 제12권 제2호

발행연도: 2012.1

수록면: 99 - 106 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p.o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p<0.05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p<0.05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.

#Eugenia jambolana #Hyperlipidemia #Oxidative stress #Histopathology

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요