지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 83 - 88 (6page)
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Objectives : The aim of this study was to investigate the asthma-suppressive and immuno-regulatory effect of Notopterygii Rhizoma(NR) extract on OVA(ovalbumin)-induced asthma in mice. Methods : C57BL/6 mice out of all the experimental groups, except the Normal group and the NRI group, were sensitized and challenged with OVA. C57BL/6 mice were exposed to OVA three times a week for 12 weeks and analyzed by flow cytometer, ELISA, H&E stain. Results : The concentrations of IL-4, IL-5, IL-13, IgE in serum of the OVA-NRII group decreased significantly compared with those of the OVA-Control group. The number of $Gr-1^+/CD11b^+$, $CCR3^+$, $CD3^+/CD19^+$, $CD3e^+/CD69^+$cells in the OVA-NRI group decreased significantly compared with those of the OVA-Control group. The collagen accumulation in the lung sections of the OVA-NRII group decredased signi- ficantly compared with that of the OVA-Control group. Conclusions : These results suggest that Notopterygii Rhizoma(NR) would be a effective candidate for herbal-originated anti-asthmatic drug. However, this drug should be further studied for characterization of the accurate action and underlying mechanism using variant disease model in the future.
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참고문헌 (19)
참고문헌 신청
The Korean Assosiation of Internal Medicine / 2003 / Harrison`s Principles of Interal Medicine / The publish MIP 2:150
Korean journal of asthma / 2002 / Asthma and allergic diseases / Koonjapulisher 13(33):13~250
Masoli / 2004 / The global burden of asthma：exrcutive summary of the Gina Dissemination Committee report / Allergy 59(5):469~478
National Health Insurance Corporation / 6 years (2002~2007) in recent times yellow sand relation spring season cluster lifestyle diseased health insurance medical institution user analysis(최근 6년 (2002～2007)간 황사관련 봄철 다발생 질환 건강보험 의 료기관 이용자 분석)
Oriental medical university herbal medicine the National History Compilation Committee / 2006 / Clinical Traditional Herbalogy / Younglimsa
Korean journal of asthma / 2002 / Asthma and allergic diseases / Koonjapulisher 13(33):13~250
Masoli / 2004 / The global burden of asthma：exrcutive summary of the Gina Dissemination Committee report / Allergy 59(5):469~478
National Health Insurance Corporation / 6 years (2002~2007) in recent times yellow sand relation spring season cluster lifestyle diseased health insurance medical institution user analysis(최근 6년 (2002～2007)간 황사관련 봄철 다발생 질환 건강보험 의 료기관 이용자 분석)
Oriental medical university herbal medicine the National History Compilation Committee / 2006 / Clinical Traditional Herbalogy / Younglimsa
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