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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 21 - 27 (7page)
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Objectives : In this study, we investigated the biological activities such as anti-obesity using Samwondan ethanol extract (SWD). SWD is a complex with Salicornia herbacea Linnaeus, Saururus chinensis Baill and Houttuynia cordata Thunberg as the main raw material.Methods : The SWD was extracted 80% ethanol. 3T3-L1 preadipocytes were induced adipogenesis by differentiation media with SWD at 1 μg/mL, 10 μg/mL, and 100 μg/mL. Effect of SWD performed using MTT assay, oil red O staining (observation by microscope), and reverse transcription polymerase chain reaction. Also we measured production of triglyceride (TG), fatty acid, and acetyl-CoA carboxylase (ACC).Results : Non-cytotoxicity was in all test group from range of 1 μg/mL to 100 μg/mL on pre-adipocyte. The droplet and production of lipid were decreased significantly by the SWD. And TG was decreased by approximately 89%, 85% and 82%, upon the SWD treatment at concentration of 1 μg/mL, 10 μg/mL, and 100 μg/mL. Moreover, the SWD showed inhibitory effects on the expression of the C/EBP (CCAAT/enhaner binding protein)β, C/EBPα, and peroxisome proliferator-activated receptorγgenes in adipocytes. The SWD at 100 μg/mL concentration showed inhibitory effect on fatty acid production by 79%. Also ACC production were decreased dose-dependently.Conclusions : From the results above, we concluded that the SWD indicated significantly anti-obesity effects.
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참고문헌 (38)
참고문헌 신청
김세건 / 2010 / 3T3-L1 세포에 대한 옻나무 추출물의 지방축적 억제효과 / 생약학회지 41(1):21~25
이경선 / 2010 / DASH다이어트와 유산소운동이 비만인의 신체조성과 혈액변인에 미치는 영향 / Journal of Exercise Nutrition & Biochemistry 14(1):17~21
박정애 / 2011 / 흑마늘 추출물에 의한 3T3-L1 지방전구세포의 분화 및 adipogenesis 억제에 관한 연구 / 생명과학회지 21(5):720~728
Heilbronn L / 2004 / Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus / Int J Obes Relat Metab Disord 28:S12~S21
Saltiel AR / 2001 / Insulin signalling and the regulation of glucose and lipid metabolism / Nature 414:799~806
이경선 / 2010 / DASH다이어트와 유산소운동이 비만인의 신체조성과 혈액변인에 미치는 영향 / Journal of Exercise Nutrition & Biochemistry 14(1):17~21
박정애 / 2011 / 흑마늘 추출물에 의한 3T3-L1 지방전구세포의 분화 및 adipogenesis 억제에 관한 연구 / 생명과학회지 21(5):720~728
Heilbronn L / 2004 / Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus / Int J Obes Relat Metab Disord 28:S12~S21
Saltiel AR / 2001 / Insulin signalling and the regulation of glucose and lipid metabolism / Nature 414:799~806
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