지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 129 - 133 (5page)
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Objectives : The purpose of this study was to investigate the effects of Angelicae acutilobae Radix Water Extract (AA) on the production of cytokines in RAW 264.7 cell stimulated with lipopolysaccharide (LPS). Method : RAW 264.7 cells were cotreated with AA (50 and $100{\mu}g/mL$) and lipopolysaccharide (LPS; $1{\mu}g/mL$) for 24 hours. After 24 hours treatment, using bead-based multiplex cytokine assay, concentrations of various cytokines such as interleukin(IL)-6, tumor necrosis factor-alpha(TNF-${\alpha}$) granulocyte colony-stimulating factor(G-CSF), granulocyte macrophage colony-stimulating factor(GM-CSF), and macrophage inflammatory protein(MIP)-$1{\alpha}$ were measured. Result : AA significantly inhibited LPS-induced production of IL-6 and MIP-$1{\alpha}$ from LPS-stimulated RAW 264.7 cells at the concentration of $50{\mu}g/mL$. AA significantly inhibited LPS-induced production of TNF-${\alpha}$ from LPS-stimulated RAW 264.7 cells at the concentration of $100{\mu}g/mL$. AA significantly inhibited LPS-induced production of G-CSF and GM-CSF in RAW 264.7 cells at the concentrations of 50 and $100{\mu}g/mL$. Conclusion : These results suggest that AA has anti-inflammatory effect related with its inhibition of proinflammatory cytokines such as IL-6, TNF-${\alpha}$, G-CSF, GM-CSF, and MIP-$1{\alpha}$ in LPS-induced macrophages.
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참고문헌 (27)
참고문헌 신청
Peter Parham / 2006 / Myeonyeokhak / LifeScience :235
Calixto JB / 2004 / Anti-inflammatory compounds of plant origin. Part Ⅱ. modulation of pro-inflammatory cytokines, chemokines and adhesion melecules / Planta Med 70(2):93~103
Lee K / 2012 / Effects of Angelica acutiloba on mast cell-mediated allergic reactions in vitro and in vivo / Immunopharmacol Immunotoxicol 34(4):571~577
Wu B / 1982 / Shennongbencaojing / Renminweishengchubanshe :64
State Administration of Traditional chiense medicine of the People’s Republic of China / 1999 / Zhonghuabencao. Vol. 5 / Shanghai Scientific and Technical Publishers :874~875
Calixto JB / 2004 / Anti-inflammatory compounds of plant origin. Part Ⅱ. modulation of pro-inflammatory cytokines, chemokines and adhesion melecules / Planta Med 70(2):93~103
Lee K / 2012 / Effects of Angelica acutiloba on mast cell-mediated allergic reactions in vitro and in vivo / Immunopharmacol Immunotoxicol 34(4):571~577
Wu B / 1982 / Shennongbencaojing / Renminweishengchubanshe :64
State Administration of Traditional chiense medicine of the People’s Republic of China / 1999 / Zhonghuabencao. Vol. 5 / Shanghai Scientific and Technical Publishers :874~875
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