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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Objectives : The aim of this study is to investigate the preventive effect of Puerariae Flos ethanol extract (PE) on methionin and choline deficient (MCD)-diet-induced Nonalcoholic fatty liver disease (NAFLD) in C57BL/6J mice. Methods : In the in vivo experiments, C57BL/6J mice were divided into 4 groups; Normal group, Control group, MCD+PE 100 group, and MCD+PE 300 group. After 4 weeks, body weight, liver weight, biochemical parameters for liver function test, histological changes, reverse transcription polymerase chain reaction (RT-PCR), and Western blot were assessed. Results : Mice lost body weight with the MCD-diet and the MCD+PE 100 group and MCD+PE 300 groups lost less than the control group, though showed no statistical significance. Liver weights were decreased by the MCD diet, but MCD+PE 300 groups were increased significantly. In the liver function test, all the values were decreased with the MCD-diet, MCD+PE 100 group and MCD+PE 300 groups were increased significance. In histological findings of the livers, MCD-diet induced severe fatty accumulation in the livers, but this fatty change was reduced in the MCD+PE 100 group and MCD+PE 300 groups was inhibited respectively. In lipid accumulation factors (such as SREBP-1c, $C/EBP{\alpha}$, PPAR-${\gamma}$), MCD+PE 100 group and MCD+PE 300 groups showed inhibitory effect on liver lipogenesis by reducing associated gene expressions caused by MCD diet. Conclusions : We were able to know that Puerariae Flos ethanol extract (PE) shown hepatoprotective effects via a decrease on the hepatic lipogenesis factors in the experimental NAFLD Models.
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참고문헌 (34)
참고문헌 신청
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Pavel S / 1983 / Eumelanin (precursor) metabolites as markers for pigmented malignant melanoma, a preliminary report / Cancer Detect Prev 6:311~316
Prota, G. / 1980 / Recent advances in the chemistry of melanogenesis in mammals / J Invest Dermatol 75:122~127
Parvez S / 2006 / Survey and mechanism of skin depigmenting and lightening agents / Phytother Res 20:921~934
Mayer A. M / 1987 / Polyphenol oxidases in plants recent progress / Phytochemistry 26:11~20
Pavel S / 1983 / Eumelanin (precursor) metabolites as markers for pigmented malignant melanoma, a preliminary report / Cancer Detect Prev 6:311~316
Prota, G. / 1980 / Recent advances in the chemistry of melanogenesis in mammals / J Invest Dermatol 75:122~127
Parvez S / 2006 / Survey and mechanism of skin depigmenting and lightening agents / Phytother Res 20:921~934
Mayer A. M / 1987 / Polyphenol oxidases in plants recent progress / Phytochemistry 26:11~20
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