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논문 기본 정보

자료유형
학술저널
저자정보
Ahn, Heesu (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Kim, Mi Hyun (FutureChem Healthcare Co., Ltd.) Han, Sang Jin (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Woo, Sang Keun (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Kim, Jung Young (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Lee, Kyu Chul (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Lim, Il Han (Division of Applied RI, Korea Institute of Radiological and Medical Sciences) Lee, Yong Jin (Division of Applied RI, Korea Institute of Radiological and Medical Sciences)
저널정보
대한방사성의약품학회 대한방사성의약품학회지 대한방사성의약품학회지 제4권 제2호
발행연도
2018.1
수록면
65 - 72 (8page)

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Prostate specific membrane antigen (PSMA) is a cell surface membrane protein, which is overexpressed in most prostate cancer. Recently, PET imaging with $[^{68}Ga]$PSMA-HBED-CC has been widely used for the diagnosis of recurrent prostate cancer and the studies on the diagnostic potential of $^{64}Cu$-labeled PSMA ligands reported actively. In this study, we monitored with biological evaluation in vivo and PET imaging of $^{64}Cu$-labeled PSMA ligand ($[^{64}Cu]$PSMA-617). The radiolabelling efficiency and stability of $[^{64}Cu]$PSMA-617 were confirmed by radio-thin layer chromatography. The radiolabeling efficiency of $[^{64}Cu]$PSMA-617 showed over 95%, and stabilities of intact remained over 98% in both human and mouse serum for 48 h. In normal male mice, in vivo uptake of $[^{64}Cu]$PSMA-617 in several organs was measured at 2, 4, 6, 24, 48 h after injection. Rapid blood clearance was observed for $[^{64}Cu]$PSMA-617. The high uptake was observed in the lung, liver, intestines and kidneys at 2 h postinjection, but was low in the other organs (1-2 %ID/g) at 4 h. The dynamic PET/CT images of 22RV1 tumor-bearing nude mice were acquired during 60 min and additionally acquired 24 h and 48 h after injection. In dynamic PET images, $[^{64}Cu]$PSMA-617 uptake ratio in tumors versus muscle was increased as time elaplsed until 60 minutes and remained in tumors at 48 h. In these results, the PET/CT imaging using $[^{64}Cu]$PSMA-617 in prostate cancer is expected to be useful for the diagnosis and treatment of prostate cancer patients.

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