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논문 기본 정보

자료유형
학술저널
저자정보
Kang, Se Hun (Molecular Imaging and Therapy Branch, Research Institute and Hospital, National Cancer Center) Kim, Seo-il (Molecular Imaging and Therapy Branch, Research Institute and Hospital, National Cancer Center) Jung, So-Youn (Center for Breast Cancer, Research Institute and Hospital, National Cancer Center) Lee, Seeyoun (Center for Breast Cancer, Research Institute and Hospital, National Cancer Center) Kim, Seok Won (Center for Breast Cancer, Research Institute and Hospital, National Cancer Center) Kim, Seok-ki (Molecular Imaging and Therapy Branch, Research Institute and Hospital, National Cancer Center)
저널정보
대한방사성의약품학회 대한방사성의약품학회지 대한방사성의약품학회지 제1권 제1호
발행연도
2015.1
수록면
62 - 73 (12page)

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We developed an evans blue-indocyanine green-$^{99m}Tc$-human serum albumin conjugate for sentinel lymph node mapping and we describe its unique potential usage for clinical implications. This conjugate has combined the strengths of visible blue dye, near-infrared fluorescence and radioisotope into one single conjugate without any additional weakness/disadvantage. All the components of evans blue-indocyanine green-$^{99m}Tc$-human serum albumin are safe and of low cost, and they have already been clinically used. This conjugate was stable in the serum, it showed a long retention time in the lymphatic system and the lymph nodes showed a much higher signal-to-noise ratio after the conjugate was injected intradermally into the paw of mice. Both the single-photon emission computed tomography and near-infrared fluorescent images of the mice were successfully obtained at the same time as the excised sentinel lymph nodes showed blue color. The visual color, near-infrared fluorescence and gamma ray from this agent could be complementary for each other in all the steps of sentinel lymph node sampling: exploring and planning sentinel lymph node before excision with visualization of the exact sentinel lymph node location during an operation. Therefore, the triple modal agent will possibly be very ideal for sentinel lymph node mapping because of the high signal-to-noise ratio for non-invasive imaging and its complementary multimodal nature, easy preparation and safety. It is promising for clinical applications and it may have great advantages over the traditional single modal methods.

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