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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 96 - 103 (8page)
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The influenza A (H1N1) virus, also known as swine flu is a leading cause of morbidity and mortality since 2009. There is a need to explore novel anti-viral drugs for overcoming the epidemics. Traditionally, different plant extracts of garlic, ginger, kalmegh, ajwain, green tea, turmeric, menthe, tulsi, etc. have been used as hopeful source of prevention and treatment of human influenza. The H1N1 virus contains an important glycoprotein, known as neuraminidase (NA) that is mainly responsible for initiation of viral infection and is essential for the life cycle of H1N1. It is responsible for sialic acid cleavage from glycans of the infected cell. We employed amino acid sequence of H1N1 NA to predict the tertiary structure using Phyre2 server and validated using ProCheck, ProSA, ProQ, and ERRAT server. Further, the modelled structure was docked with thirteen natural compounds of plant origin using AutoDock4.2. Most of the natural compounds showed effective inhibitory activity against H1N1 NA in binding condition. This study also highlights interaction of these natural inhibitors with amino residues of NA protein. Furthermore, among 13 natural compounds, theaflavin, found in green tea, was observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Hence, it may be of interest to consider theaflavin for further in vitro and in vivo evaluation.
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참고문헌 (33)
참고문헌 신청
Behera DK / 2012 / In silico biology of H1N1: molecular modelling of novel receptors and docking studies of inhibitors to reveal new insight in flu treatment / J Biomed Biotechnol 2012:714623
Gallaher WR. / 2009 / Towards a sane and rational approach to management of Influenza H1N1 2009 / Virol J 6:51
Harrison SC. / 2008 / Viral membrane fusion / Nat Struct Mol Biol 15:690~698
Burmeister WP / 1992 / The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid / EMBO J 11:49~56
Eiland LS / 2007 / Zanamivir for the prevention of influenza in adults and children age 5 years and older / Ther Clin Risk Manag 3:461~465
Gallaher WR. / 2009 / Towards a sane and rational approach to management of Influenza H1N1 2009 / Virol J 6:51
Harrison SC. / 2008 / Viral membrane fusion / Nat Struct Mol Biol 15:690~698
Burmeister WP / 1992 / The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid / EMBO J 11:49~56
Eiland LS / 2007 / Zanamivir for the prevention of influenza in adults and children age 5 years and older / Ther Clin Risk Manag 3:461~465
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