지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 140 - 146 (7page)
이용수
초록· 키워드
오류제보하기
Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. Activating transcription factor 3 (ATF3) is associated with apoptosis in human colon cancer cells. This study was performed to investigate the molecular mechanism by which NAR stimulates ATF3 expression and apoptosis in human colon cancer cells. NAR reduced the cell viability and induced an apoptosis in human colon cancer cells. ATF3 overexpression increased NAR-mediated cleaved PARP, while ATF3 knockdown attenuated the cleavage of PARP by NAR. NAR increased ATF3 expression in both protein and mRNA level, and increased the luciferase activity of ATF3 promoter in a dose-dependent manner. The responsible region for ATF3 transcriptional activation by NAR is located between -317 and -148 of ATF3 promoter. p38 inhibition blocked NAR-mediated ATF3 expression, its promoter activation and apoptosis. The results suggest that NAR induces apoptosis through p38-dependent ATF3 activation in human colon cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Ahamad, M. S / 2014 / Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinoma cell through ROS generation and cell cycle arrest / PLoS One 9:e110003
Baek, S. J / 2004 / Epicatechin gallate-induced expression of NAG-1is associated with growth inhibition and apoptosis in colon cancer cells / Carcinogenesis 25:2425~2432
Bleiberg, H / 2012 / A phase II randomized study of combined infusional leucovorin sodium and 5- FU versus the leucovorin calcium followed by 5-FU both in combination with irinotecan or oxaliplatin in patients with metastatic colorectal cancer / Acta Gastroenterol. Belg 75:14~21
Bulzomi, P / 2012 / The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background / IUBMB Life 64:690~696
Cai, Y / 2000 / Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element / Blood 96:2140~2148
Baek, S. J / 2004 / Epicatechin gallate-induced expression of NAG-1is associated with growth inhibition and apoptosis in colon cancer cells / Carcinogenesis 25:2425~2432
Bleiberg, H / 2012 / A phase II randomized study of combined infusional leucovorin sodium and 5- FU versus the leucovorin calcium followed by 5-FU both in combination with irinotecan or oxaliplatin in patients with metastatic colorectal cancer / Acta Gastroenterol. Belg 75:14~21
Bulzomi, P / 2012 / The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background / IUBMB Life 64:690~696
Cai, Y / 2000 / Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element / Blood 96:2140~2148
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
ATF3 Mediates Anti-Cancer Activity of Trans-10, cis-12-Conjugated Linoleic Acid in Human Colon Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Anti-Proliferative Effect of Naringenin through p38-Dependent Downregulation of Cyclin D1 in Human Colorectal Cancer Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
The upregulation of p50ATF6 in the testis increased apoptosis in response to cadmium exposure
한국실험동물학회 학술발표대회 논문집
2023 .02
-
Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities
The Korean Journal of Pain
2022 .07
-
Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages
The Korean Journal of Physiology & Pharmacology
2016 .07
-
Survival analysis for colon subsite and rectal cancers : Experience from a single surgeon
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2015 .12
-
Cigarette smoke components induced apoptosis in SW620 human colon cancer cells via ROS-induced ER-stress pathway
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Kaempferol Synergistically Enhances Cisplatin-induced Apoptosis and Cell Cycle Arrest in Colon Cancer Cells
대한암예방학회지
2024 .09
-
Right-Sided and Left-Sided Colon Cancers are Two Distinct Disease Entities: an Analysis of 200 Cases in Pakistan
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Nanomaterials for chondrogenesis
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Recurrence of Advanced Colon Cancer after Endoscopic Resection for Early Colon Cancer with Slight Submucosal Invasion: A Case Report
대한외과학회 학술대회 초록집
2020 .11
-
The Prognosis and Recurrence Pattern of Right- and Left-Sided Colon Cancer in Stage II, Stage III, and Liver Metastasis After Curative Resection
Annals of Coloproctology
2021 .10
-
C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia
PSYCHIATRY INVESTIGATION
2020 .01
-
Is radical surgery for clinical stage I right-sided colon cancer relevant? A retrospective review
Annals of Surgical Treatment and Research
2020 .03
-
Metastatic colon cancer of an ovarian cancer origin mimicking primary colon cancer : A case report
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Activating transcription factor 4 aggravates angiotensin II-induced cell dysfunction in human vascular aortic smooth muscle cells via transcriptionally activating fibroblast growth factor 21
The Korean Journal of Physiology & Pharmacology
2022 .09
-
Recurrent interval period according to stage of colon cancer
대한외과학회 학술대회 초록집
2017 .11
-
Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein–Coupled Receptor 30
Cancer Research and Treatment
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0