지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 553 - 561 (9page)
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초록· 키워드
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Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast, vagina, cervix, the gastrointestinal tract, and skin. Rab25 plays key roles in tumorigenesis, mainly by regulating epithelial differentiation and proliferation. However, its role in skin physiology is relatively unknown. In this study, we demonstrated that Rab25 knock-out (KO) mice show a skin barrier dysfunction with high trans-epidermal water loss and low cutaneous hydration. To examine this observation, we investigated the histology and epidermal differentiation markers of the skin in Rab25 KO mice. Rab25 KO increased cell proliferation at the basal layer of epidermis, whereas the supra-basal layer remained unaffected. Ceramide, which is a critical lipid component for skin barrier function, was not altered by Rab25 KO in its distribution or amount, as determined by immunohistochemistry. Notably, levels of epidermal differentiation markers, including loricrin, involucrin, and keratins (5, 14, 1, and 10) increased prominently in Rab25 KO mice. In line with this, depletion of Rab25 with single hairpin RNA increased the expression of differentiation markers in a human keratinocyte cell line, HaCaT. Transcriptomic analysis of the skin revealed increased expression of genes associated with skin development, epidermal development, and keratinocyte differentiation in Rab25 KO mice. Collectively, these results suggested that Rab25 is involved in the regulation of epidermal differentiation and proliferation.
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등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Bickenbach, J. R / 1995 / Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development / J. Invest. Dermatol 104:405~410
Brakebusch, C / 2000 / Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes / EMBO J 19:3990~4003
Calautti, E / 2005 / Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death / J. Biol. Chem 280:32856~32865
Casanova, J. E / 1999 / Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells / Mol. Biol. Cell 10:47~61
Cheng, K. W / 2012 / Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress / EMBO Mol. Med 4:125~141
Brakebusch, C / 2000 / Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes / EMBO J 19:3990~4003
Calautti, E / 2005 / Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death / J. Biol. Chem 280:32856~32865
Casanova, J. E / 1999 / Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells / Mol. Biol. Cell 10:47~61
Cheng, K. W / 2012 / Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress / EMBO Mol. Med 4:125~141
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