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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 39 - 44 (6page)
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In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the only source of nutrient, it can serve for both biosynthesis and energy production. However, a series of studies revealed that the cancer cell consumes glucose for biosynthesis through fermentation, not for energy supply, under physiological conditions. Recently, a new observation was made that there is a metabolic symbiosis in which glycolytic and oxidative tumor cells mutually regulate their energy metabolism. Hypoxic cancer cells use glucose for glycolytic metabolism and release lactate which is used by oxygenated cancer cells. This study challenged the Warburg effect, because Warburg claimed that fermentation by irreversible damaging of mitochondria is a fundamental cause of cancer. However, recent studies revealed that mitochondria in cancer cell show active function of oxidative phosphorylation although TCA cycle is stalled. It was also shown that blocking cytosolic NADH production by aldehyde dehydrogenase inhibition, combined with oxidative phosphorylation inhibition, resulted in up to 80% decrease of ATP production, which resulted in a significant regression of tumor growth in the NSCLC model. This suggests a new theory that NADH production in the cytosol plays a key role of ATP production through the mitochondrial electron transport chain in cancer cells, while NADH production is mostly occupied inside mitochondria in normal cells.
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참고문헌 (22)
참고문헌 신청
Carracedo, A. / 2013 / Cancer metabolism: fatty acid oxidation in the limelight / Nat. Rev. Cancer 13:227~232
Chandel, N. S. / 1997 / Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes / J. Biol. Chem. 272:18808~18816
Cheong, J. H. / 2011 / Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models / Mol. Cancer Ther. 10:2350~2362
DeBerardinis, R. J. / 2008 / The biology of cancer: metabolic reprogramming fuels cell growth and proliferation / Cell Metab. 7:11~20
DeBerardinis, R. J. / 2007 / Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis / Proc. Natl. Acad. Sci. U.S.A. 104:19345~19350
Chandel, N. S. / 1997 / Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes / J. Biol. Chem. 272:18808~18816
Cheong, J. H. / 2011 / Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models / Mol. Cancer Ther. 10:2350~2362
DeBerardinis, R. J. / 2008 / The biology of cancer: metabolic reprogramming fuels cell growth and proliferation / Cell Metab. 7:11~20
DeBerardinis, R. J. / 2007 / Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis / Proc. Natl. Acad. Sci. U.S.A. 104:19345~19350
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