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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Yukyung (Department of Nuclear Medicine, Gachon University Gil Hospital) Hwang, Kyung Hoon (Department of Nuclear Medicine, Gachon University Gil Hospital) Hong, Junshik (Department of Internal Medicine, Gachon University Gil Hospital) Park, Jinny (Department of Internal Medicine, Gachon University Gil Hospital) Lee, Jae Hoon (Department of Internal Medicine, Gachon University Gil Hospital) Ahn, Jeong Yeal (Department of laboratory Medicine, Gachon University Gil Hospital) Kim, Ji Hyun (Department of Nuclear Medicine, Gachon University Gil Hospital) Lee, Haejun (Department of Nuclear Medicine, Gachon University Gil Hospital) Kim, Seog Gyun (Department of Nuclear Medicine, Gachon University Gil Hospital) Shin, Ji Young (Department of Internal Medicine, Gachon University Gil Hospital)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제46권 제4호
발행연도
2012.1
수록면
269 - 277 (9page)

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Purpose To assess the usefulness of $^{18}F$-fluorodeoxyglucose PET/CT in the detection of bone marrow (BM) involvement of high-grade non-Hodgkin's lymphoma (NHL). Methods One hundred twenty patients with newly diagnosed diffuse large B-cell lymphoma or peripheral T-cell lymphoma between January 2007 and June 2011, who received BM trephine biopsy and $^{18}F$-FDG PET/CT before chemotherapy, were included in this retrospective study. We reviewed their $^{18}F$-FDG PET/CT images and bone marrow biopsy (BMB) results. After reviewing the images, we reviewed the medical records and radiological findings of interesting patients. Results There were 23 $^{18}F$-FDG PET/CT scans in which the marrow was considered to be abnormal (either positive or equivocal), and 97 $^{18}F$-FDG PET/CT scans were regarded as having negative FDG uptake. Of 120 patients, 100 (83.3 %) had a concordant result of BM interpretation between $^{18}F$-FDG PET/CT and BMB, and the remaining 20 patients had discordant results. Among 23 patients with either positive or equivocal $^{18}F$-FDG PET/CT scans, 1 of 12 patients with 'positive' $^{18}F$-FDG PET/CT had a lymphomatous involvement on BMB. In contrast, 10 of 11 patients with 'equivocal' BM hypermetabolism were reported as having positive involvement by BMB. Patients with abnormal $^{18}F$-FDG PET/CT had significantly higher $mSUV_{highest}$ than those with normal FDG-PET/CT. Conclusions $^{18}F$-FDG PET/CT and BMB are complementary techniques in assessing the presence of BM involvement in patients with high-grade NHL. The increasing availability of $^{18}F$-FDG PET/CTwill raise the need for additional biopsy for FDG-avid lesions, especially in patients with negative standard BMBs. $^{18}F$-FDG PET/CT can be useful as a decision-making tool for determining whether to perform a standard BMB or targeted biopsy to the FDG-avid lesion as an initial staging procedure.A direct bone biopsy for FDGpositive bone lesions should be included in staging guidelines in future. In $^{18}F$-FDG PET/CT-negative cases, BMB is still a powerful procedure, but BMB alone is insufficient for full evaluation of BM.

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