Down-regulation of miRNA-452 is Associated with Adriamycin-resistance in Breast Cancer Cells

Hu, Qing; Gong, Jian-Ping; Li, Jian; Zhong, Shan-Liang; Chen, Wei-Xian; Zhang, Jun-Ying; Ma, Teng-Fei; Ji, Hao; Lv, Meng-Meng; Zhao, Jian-Hua; Tang, Jin-Hai

추천

검색

자료유형: 학술저널

저자정보: Hu, Qing (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Gong, Jian-Ping (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Li, Jian (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Zhong, Shan-Liang (Clinical Laboratory Center, Jiangsu Cancer Hospital) Chen, Wei-Xian (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Zhang, Jun-Ying (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Ma, Teng-Fei (Clinical Laboratory Center, Jiangsu Cancer Hospital) Ji, Hao (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Lv, Meng-Meng (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital) Zhao, Jian-Hua (Clinical Laboratory Center, Jiangsu Cancer Hospital) Tang, Jin-Hai (Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제13호

발행연도: 2014.1

수록면: 5,137 - 5,142 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Adriamycin (ADR) is an important chemotherapeutic agent frequently used in treatment of breast cancer. However, resistance to ADR results in treatment failure in many patients. Recent studies have indicated that microRNAs (miRNAs) may play an important role in such drug-resistance. In the present study, microRNA-452 (miR-452) was found to be significantly down-regulated in adriamycin-resistant MCF-7 cells (MCF-7/ADR) compared with the parental MCF-7 cells by miRNA microarray and real-time quantitative PCR (RT-qPCR). MiR-452 mimics and inhibitors partially changed the adriamycin-resistance of breast cancer cells, as also confirmed by apoptosis assay. In exploring the potential mechanisms of miR-452 in the adriamycin-resistance of breast cancer cells, bioinformatics analysis, RT-qPCR and Western blotting showed that dysregulation of miR-452 played an important role in the acquired adriamycin-resistance of breast cancer, maybe at least in part via targeting insulin-like growth factor-1 receptor (IGF-1R).

#MicroRNA-452 #breast cancer #adriamycin #IGF-1R #chemosensitivity

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Hu, Qing

소속기관 Department of General Surgery, Nanjing Medical University Affiliated Jiangsu Cancer Hospital