Association of Matrix Metalloproteinase (MMP)-2 and -9 Expression with Extra-gastrointestinal Stromal Tumor Metastasis

Wang, Chao; Ma, Hong-Xi; Jin, Mei-Shan; Zou, Ya-Bin; Teng, Yong-Liang; Tian, Zhuang; Wang, Hai-Ying; Wang, Yin-Ping; Duan, Xiu-Mei

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자료유형: 학술저널

저자정보: Wang, Chao (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Ma, Hong-Xi (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Jin, Mei-Shan (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Zou, Ya-Bin (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Teng, Yong-Liang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Tian, Zhuang (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Wang, Hai-Ying (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Wang, Yin-Ping (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University) Duan, Xiu-Mei (Pathological Diagnosis Centre, The First Hospital Affiliated to Bethune Medical College, Jilin University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제10호

발행연도: 2014.1

수록면: 4,187 - 4,192 (6page)

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Matrix metalloproteinase (MMP)-2 and MMP-9 are important proteases involved in invasion and metastasis of various tumors. Extra-gastrointestinal stromal tumors (EGISTs) are rare neoplasms. This study was performed to assess MMP-2 and MMP-9 expression in EGIST tissue samples for association with clinicopathological data from the patients. Twenty-one surgical EGIST tissue specimens were collected for analysis of MMP-2 and MMP-9 expression using immunohistochemistry. MMP-2 and MMP-9 proteins were expressed in all of the epithelial cell types of EGISTs, whereas they were only expressed in 75% of the spindle cell type, although there was no statistically significant difference (p>0.05). Expression of MMP-2 and MMP-9 proteins was associated with tumor size, mitotic rate, tumor necrosis, and distant metastasis (p<0.05). MMP-2 expression was linked with MMP-9 levels (p<0.05). However, there was no correlation between MMP-9 expression and age, sex, primary site, or cell morphology in any of these 21 EGIST patients (p>0.05). Moreover, expression of MMP-2 and MMP-9 proteins increased with the degree of EGIST risk. This study provided evidence of an association of MMP-2 and MMP-9 expression with advanced EGIST behavior.

#Extra #gastrointestinal stromal tumor #EGIST) #MMP-2 #MMP-9 #tumor invasion and metastasis #biomarker

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