Study on the Relationship Between CXCR4 Expression and Perineural Invasion in Pancreatic Cancer

Jiang, Yu-Mei; Li, Guang; Sun, Bao-Cun; Zhao, Xiu-Lan; Zhou, Zhong-Kai

추천

검색

자료유형: 학술저널

저자정보: Jiang, Yu-Mei (Key Laboratory of Food Nutrition and Safety Ministry of Education, Tianjin University of Science and Technology, Tianjin International Joint Academy of Biomedicine) Li, Guang (Department of Biology, Tianjin Medical University) Sun, Bao-Cun (Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University) Zhao, Xiu-Lan (Department of Pathology, Tianjin Cancer Hospital, Tianjin Medical University) Zhou, Zhong-Kai (Key Laboratory of Food Nutrition and Safety Ministry of Education, Tianjin University of Science and Technology, Tianjin International Joint Academy of Biomedicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제12호

발행연도: 2014.1

수록면: 4,893 - 4,896 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Recent reports have shown that C-X-C chemokine receptor 4 (CXCR4) plays an important role in metastasis. Despite a clear understanding of the protein's structure and properties, its functional role remains elusive. We conducted the present study to evaluate the expressions of CXCR4 in pancreatic cancer, and to investigate its relationship with clinicopathological parameters, especially perineural invasion(PNI). Materials and Methods: The association between CXCR4 expression and perineural invasion was determined by immunohistochemistry in pancreatic cancer patients (n=51). Results: CXCR4 expression was correlated with the existence of PNI and the type of PNI (p=0.042, p=0.040). TIMP-2 expression was also correlated with the existence, the pathway and degree of PNI (p=0.000, p=0.006, p=0.000). Conclusions: Our results suggest an association between PNI and expression of CXCR4 and TIMP-2 in pancreatic cancer. CXCR4 may promote the occurrence of PNI in pancreatic cancer cells by decreasing the inhibition of TIMPs on MMP.

#Pancreatic cancer #Perineural invasion #CXCR4 #TIMP-2

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Jiang, Yu-Mei

소속기관 Key Laboratory of Food Nutrition and Safety Ministry of Education, Tianjin University of Science and