Predicting Lympho-Vascular Space Invasion in Endometrial Cancers with Mucinous Carcinomatous Components

Ilker, Selcuk; Nilufer, Cetinkaya; Firat, Cuylan Zeliha; Bulent, Ozdal; Hatice, Bayramoglu; Tayfun, Gungor

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자료유형: 학술저널

저자정보: Ilker, Selcuk (Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital) Nilufer, Cetinkaya (Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital) Firat, Cuylan Zeliha (Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital) Bulent, Ozdal (Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital) Hatice, Bayramoglu (Pathology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital) Tayfun, Gungor (Department of Obstetrics and Gynecology, Hitit University, Faculty of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,247 - 4,250 (4page)

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Objective: To determine the predictors of lympho-vascular space invasion (LVSI) in endometrial cancers which contain mucinous carcinomatous histology. Materials and Methods: Clinical and histopathological data of endometrial carcinomas with a mucinous carcinomatous component diagnosed between January 2007 and January 2014 at the Gynecologic Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively. Results: Twelve patients (25.5%) were positive for LVSI and 35 (74.5%) patients were negative. Patients with LVSI were mostly staged higher than 1A. Mean age, BMI and parity were not significantly different between patient groups. Larger tumor diameter (${\geq}2cm$) (p=0.04) and elevated Ca125 and Ca-19.9 (p=0.01) levels were significant for predicting LVSI. We also found>1/2 myometrial invasion (p<0.001), cervical stromal involvement (p=0.002) and higher grade (2-3) (p=0.001) significant for predicting LVSI. In multivariate analysis we found only grade significant for predicting LVSI. Conclusions: Especially grade of tumor is a crucial factor for determining LVSI in endometrial cancers with mucinous carcinomatous components.

#Endometrial #carcinoma #mucinous #grade #LVSI

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Ilker, Selcuk

소속기관 Gynecologic Oncology Unit, Zekai Tahir Burak Women's Health, Education and Research Hospital