Clinical Predictive Value of Serum Angiogenic Factor in Patients with Osteosarcoma

Chen, Zhe; Chen, Qi-Xin; Hou, Zhao-Yang; Hu, Jiong; Cao, Yan-Guang

추천

검색

자료유형: 학술저널

저자정보: Chen, Zhe (Department of Orthopaedics, The Second Affiliated Hospital, Medical College, Zhejiang University) Chen, Qi-Xin (Department of Orthopaedics, The Second Affiliated Hospital, Medical College, Zhejiang University) Hou, Zhao-Yang (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University) Hu, Jiong (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University) Cao, Yan-Guang (Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang Chinese Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제9호

발행연도: 2012.1

수록면: 4,823 - 4,826 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: To explore serum angiogenic factor expression in patients with osteosarcoma and its relationship with metastasis. Methods: Immunohistochemistry was used to test the expression of CD34 and FVIII-Rag in osteosarcoma tissues of 36 patients (osteosarcoma group) and microvessel density (MVD) was also recorded. In addition, ELISA was used to test the level of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor-${\beta}1$ (TGF-${\beta}1$) and endostatin (ES) in the osteosarcoma group and in a control group. Results: VEGF and ES level were significantly higher than in the control group before operation (P<0.01), VEGF, bFGF and TGF-${\beta}1$ correlating with the ES level (P<0.01). Serum VEGF and ES levels of osteosarcoma patients before surgery were closely related to relapse and metastasis; moreover, serum VEGF increased with MVD (P<0.01). Postoperative VEGF and ES levels were lower than the preoperation values (P<0.01); ES level in relapse group was significantly higher than that of the non-relapse group (P<0.01). Conclusion: Preoperative serum VEGF and postoperative ES levels have great predictive value with regard to relapse of osteosarcoma patients.

#Osteosarcoma #angiogenic facor #microvessel density

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Chen, Zhe

소속기관 Zhejiang Provincial Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University