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논문 기본 정보

자료유형
학술저널
저자정보
Lee, Eun Ji (Department of Biological Science, Sookmyung Women's University) Park, Jong Hoon (Department of Biological Science, Sookmyung Women's University)
저널정보
한국유전체학회 Genomics & informatics Genomics & informatics 제11권 제4호
발행연도
2013.1
수록면
224 - 229 (6page)

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Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein, amyloid-${\beta}$-protein, Mac-1, and phosphatidylserine. Its interaction is engaged in critical cellular processes, such as inflammation, proliferation, apoptosis, autophagy, and migration, and dysregulation of RAGE and its ligands leads to the development of numerous human diseases. In this review, we summarize the signaling pathways regulated by RAGE and its ligands identified up to date and demonstrate the effects of hyper-activation of RAGE signals on human diseases, focused mainly on renal disorders. Finally, we propose that RAGE and its ligands are the potential targets for the diagnosis, monitoring, and treatment of numerous renal diseases.

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