지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 93 - 96 (4page)
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초록· 키워드
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The prediction of externally visible characteristics from DNA has been studied for forensic genetics over the last few years. Externally visible characteristics include hair, skin, and eye color, height, and facial morphology, which have high heritability. Recent studies using genome-wide association analysis have identified genes and variations that correlate with human visible phenotypes and developed phenotype prediction programs. However, most prediction models were constructed and validated based on genotype and phenotype information on Europeans. Therefore, we need to validate prediction models in diverse ethnic populations. In this study, we selected potentially useful variations for forensic science that are associated with hair and eye color, iris pattern, and facial morphology, based on previous studies, and analyzed their frequencies in 1,920 Koreans. Among 20 single nucleotide polymorphisms (SNPs), 10 SNPs were polymorphic, 6 SNPs were very rare (minor allele frequency < 0.005), and 4 SNPs were monomorphic in the Korean population. Even though the usability of these SNPs should be verified by an association study in Koreans, this study provides 10 potential SNP markers for forensic science for externally visible characteristics in the Korean population.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Jobling MA / 2004 / Encoded evidence: DNA in forensic analysis / Nat Rev Genet 5:739~751
Dixon LA / 2005 / Validation of a 21-locus autosomal SNP multiplex for forensic identification purposes / Forensic Sci Int 154:62~77
Sanchez JJ / 2006 / A multiplex assay with 52 single nucleotide polymorphisms for human identification / Electrophoresis 27:1713~1724
Budowle B / 2008 / Forensically relevant SNP classes / Biotechniques 44:603~610
Kayser M / 2011 / Improving human forensics through advances in genetics, genomics and molecular biology / Nat Rev Genet 12:179~192
Dixon LA / 2005 / Validation of a 21-locus autosomal SNP multiplex for forensic identification purposes / Forensic Sci Int 154:62~77
Sanchez JJ / 2006 / A multiplex assay with 52 single nucleotide polymorphisms for human identification / Electrophoresis 27:1713~1724
Budowle B / 2008 / Forensically relevant SNP classes / Biotechniques 44:603~610
Kayser M / 2011 / Improving human forensics through advances in genetics, genomics and molecular biology / Nat Rev Genet 12:179~192
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