지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 152 - 160 (9page)
이용수
초록· 키워드
오류제보하기
Hypertension is the major factor of most death and high blood pressure (BP) can lead to stroke, myocardial infarction and cardiac failure. Moreover, hypertension is strongly correlated with body mass index (BMI). Although the exact causes of hypertension are still unclear, some of genetic loci were discovered from genome-wide association study (GWAS). Therefore, it is essential to study genetic variation for finding more genetic factor affecting hypertension. The purpose of our study is to conduct a CNV association study for hypertension-related traits, BP and BMI, in Korean individuals. We identified 2,206 CNV regions from 3,274 community-based Korean participants using the Affymetrix Genome-Wide Human SNP Array 6.0 platform and performed a logistic regression analysis of CNVs with two hypertension-related traits, BP and BMI. Moreover, the 4,692 participants in an independent cohort were selected for respective replication analyses. GWAS of CNV identified two loci encompassing previously known hypertension-related genes: LPA (lipoprotein) on 6q26, and JAK2 (Janus kinase 2) on 9p24, with suggestive p-values (0.0334 for LPA and 0.0305 for JAK2 ). These two positive findings, however, were not evaluated in the replication stage. Our result confirmed the conclusion of CNV study from the WTCCC suggesting weak association with common diseases. This is the first study of CNV association study with BP and BMI in Korean population and it provides a state of CNV association study with common human diseases using SNP array.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Charchar, F.J / 2010 / Whole-genome survey of copy number variation in the Spontaneously Hypertensive Rat: Relationship to quantitative trait loci, gene expression, and blood pressure / Hypertension 55:1231~1238
Cho, Y.S. / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat. Genet 41:527~534
Deo, R.C / 2011 / Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans / PLoS One 6:14581
Dorajoo, R. / 2011 / Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations / Int. J . Obes
Estivill, X / 2007 / Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies / PLoS Genet 3:1787~1799
Cho, Y.S. / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat. Genet 41:527~534
Deo, R.C / 2011 / Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans / PLoS One 6:14581
Dorajoo, R. / 2011 / Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations / Int. J . Obes
Estivill, X / 2007 / Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies / PLoS Genet 3:1787~1799
이 논문의 저자 정보
최근 본 자료
댓글(0)
0