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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 29 - 33 (5page)
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A retron is a bacterial retroelement that encodes an RNA gene and a reverse transcriptase (RT). The former, once transcribed, works as a template primer for reverse transcription by the latter. The resulting DNA is covalently linked to the upstream part of the RNA; this chimera is called multicopy single-stranded DNA (msDNA), which is extrachromosomal DNA found in many bacterial species. Based on the conserved features in the eight known msDNA sequences, we developed a detection method and applied it to scan National Center for Biotechnology Information (NCBI) RefSeq bacterial genome sequences. Among 16,844 bacterial sequences possessing a retron-type RT domain, we identified 48 unique types of msDNA. Currently, the biological role of msDNA is not well understood. Our work will be a useful tool in studying the distribution, evolution, and physiological role of msDNA.
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참고문헌 (10)
참고문헌 신청
Inouye S / 1990 / Two independent retrons with highly diverse reverse transcriptases in Myxococcus xanthus / Proc Natl Acad Sci U S A 87:942~945
Lima TM / 1997 / A novel retron that produces RNA-less msDNA in Escherichia coli using reverse transcriptase / Plasmid 38:25~33
Inouye S / 1999 / Highly specific recognition of primer RNA structures for 2'-OH priming reaction by bacterial reverse transcriptases / J Biol Chem 274:31236~31244
Borodovsky M / 1993 / GeneMark: parallel gene recognition for both DNA strands / Comput Chem 17:123~133
Tao Tao / 3.5 RPS BLAST
Lima TM / 1997 / A novel retron that produces RNA-less msDNA in Escherichia coli using reverse transcriptase / Plasmid 38:25~33
Inouye S / 1999 / Highly specific recognition of primer RNA structures for 2'-OH priming reaction by bacterial reverse transcriptases / J Biol Chem 274:31236~31244
Borodovsky M / 1993 / GeneMark: parallel gene recognition for both DNA strands / Comput Chem 17:123~133
Tao Tao / 3.5 RPS BLAST
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