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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 571 - 581 (11page)
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${\beta}$-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of this study was to examine whether BAS improved spatial cognitive impairment induced in rats following chronic corticosterone (CORT) administration. CORT administration (40 mg/kg, i.p., 21 days) resulted in cognitive impairment in the avoidance conditioning test (AAT) and the Morris water maze (MWM) test that was reversed by BAS (200 mg/kg, i.p). Additionally, as assessed by immunohistochemistry and RT-PCR analysis, the administration of BAS significantly alleviated memory-associated decreases in the expression levels of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) proteins and mRNAs in the hippocampus. Also, BAS administration significantly restored the expression of Bax and Bcl-2 mRNAs in the hippocampus. Thus, BAS may be an effective therapeutic for learning and memory disturbances, and its neuroprotective effect was mediated, in part, by normalizing the CORT response, resulting in regulation of BDNF and CREB functions and anti-apoptosis in rats.
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참고문헌 (50)
참고문헌 신청
Aisen, P. S. / 2000 / A randomized controlled trial of prednisone in Alzheimer's disease. Alzheimer's Disease Cooperative Study / Neurology 54:588~593
Alkadhi, K. A. / 2010 / Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease / Mol. Cell. Neurosci 45:289~296
Bekinschtein, P. / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc. Natl. Acad Sci. U.S.A 105:2711~2716
Browne, K. D. / 2006 / Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats / Exp. Neurol 201:301~307
Chen, Y. / 2014 / β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice / Brain Res 1552:41~54
Alkadhi, K. A. / 2010 / Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease / Mol. Cell. Neurosci 45:289~296
Bekinschtein, P. / 2008 / BDNF is essential to promote persistence of long-term memory storage / Proc. Natl. Acad Sci. U.S.A 105:2711~2716
Browne, K. D. / 2006 / Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats / Exp. Neurol 201:301~307
Chen, Y. / 2014 / β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice / Brain Res 1552:41~54
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