지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 80 - 90 (11page)
이용수
초록· 키워드
오류제보하기
Initial discovery on sphingosine 1-phosphate (S1P) as an intracellular second messenger was faced unexpectedly with roles of S1P as a first messenger, which subsequently resulted in cloning of its G protein-coupled receptors, $S1P_{1-5}$. The molecular identification of S1P receptors opened up a new avenue for pathophysiological research on this lipid mediator. Cellular and molecular in vitro studies and in vivo studies on gene deficient mice have elucidated cellular signaling pathways and the pathophysiological meanings of S1P receptors. Another unexpected finding that fingolimod (FTY720) modulates S1P receptors accelerated drug discovery in this field. Fingolimod was approved as a first-in-class, orally active drug for relapsing multiple sclerosis in 2010, and its applications in other disease conditions are currently under clinical trials. In addition, more selective S1P receptor modulators with better pharmacokinetic profiles and fewer side effects are under development. Some of them are being clinically tested in the contexts of multiple sclerosis and other autoimmune and inflammatory disorders, such as, psoriasis, Crohn's disease, ulcerative colitis, polymyositis, dermatomyositis, liver failure, renal failure, acute stroke, and transplant rejection. In this review, the authors discuss the state of the art regarding the status of drug discovery efforts targeting S1P receptors and place emphasis on potential clinical applications.
목차
등록된 정보가 없습니다.
참고문헌 (132)
참고문헌 신청
Adachi, K. / 2008 / FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology / Perspect. Medicin. Chem 1:11~23
An, S. / 1997 / Identification of cDNAs encoding two G proteincoupled receptors for lysosphingolipids / FEBS Lett 417:279~282
Asle-Rousta, M. / 2013 / Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer’s disease model rats / EXCLI J 12:449~461
Awad, A. S. / 2006 / Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney / Am. J. Physiol. Renal Physiol 290:F1516~F1524
Billich, A. / 2003 / Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases / J. Biol. Chem 278:47408~47415
An, S. / 1997 / Identification of cDNAs encoding two G proteincoupled receptors for lysosphingolipids / FEBS Lett 417:279~282
Asle-Rousta, M. / 2013 / Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer’s disease model rats / EXCLI J 12:449~461
Awad, A. S. / 2006 / Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney / Am. J. Physiol. Renal Physiol 290:F1516~F1524
Billich, A. / 2003 / Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases / J. Biol. Chem 278:47408~47415
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics
Endocrinology and Metabolism
2021 .01
-
Sphingosine -1 -phosphate (S1P) receptor modulator ameliorates systemic lupus erythematosus via regulation of autoreactive T cell and B cell function
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Changes in the Multiple Sclerosis Treatment Paradigm. What Do We Do Now and What Were We Doing Before?
Journal of Clinical Neurology
2018 .01
-
Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients
Immune Network
2018 .10
-
Conceptual Progress for the Improvements in the Selectivity and Efficacy of G Protein-Coupled Receptor Therapeutics: An Overview
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Effects of ginseng on two main sex steroid hormone receptors : estrogen and androgen receptors
Journal of Ginseng Research
2017 .04
-
Human CD8+ T-Cell Populations That Express Natural Killer Receptors
Immune Network
2023 .02
-
Roles of Dopamine D<sub>2</sub> Receptor Subregions in Interactions with β-Arrestin2
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Sphingosine-1-Phosphate: Biomarker, Contributor, or Target for Asthma?
Allergy, Asthma & Immunology Research
2019 .01
-
Oral Disease-Modifying Therapies for Multiple Sclerosis
Journal of Clinical Neurology
2015 .01
-
Expression of Growth Factor Receptor Family Before and After Targeted Therapy in Human Epidermal Growth Factor Receptor-2 Positive Breast Cancer Tissues
대한임상종양학회 학술대회지
2015 .02
-
Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval
Journal of Korean Medical Science
2024 .04
-
Animal Models in Drug Discovery : an Industry Perspective
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Expression of Estrogen and Progesterone Receptors in Papillary Thyroid Carcinoma in Korea
Cancer Research and Treatment
2021 .10
-
The Role of Bile Acid Receptors in Chronic Inflammatory Diseases
대한류마티스학회지
2017 .01
-
P2Y<sub>6</sub> 수용체 길항제의 파골세포 분화 촉진 효과 규명
약학회지
2015 .01
-
Scavenger Receptor Class A to E Involved in Various Cancers
전남의대학술지
2020 .01
-
Administration of Alpha<sub>s1</sub>-Casein Hydrolysate Increases Sleep and Modulates GABA<sub>A</sub> Receptor Subunit Expression
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Expression of growth factor receptor family before and after targeted therapy in human epidermal growth factor receptor-2 positive breast cancer tissues
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2015 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0