지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 532 - 539 (8page)
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초록· 키워드
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Peripheral neuropathy induced by human immunodeficiency virus (HIV) infection and antiretroviral therapy is not only difficult to distinguish in clinical practice, but also difficult to relieve the pain symptoms by analgesics because of the severity of the disease at the later stage. Hence, to explore the mechanisms of HIV-related neuropathy and find new therapeutic options are particularly important for relieving neuropathic pain symptoms of the patients. In the present study, primary cultured embryonic rat dorsal root ganglion (DRG) neurons were used to determine the neurotoxic effects of HIV-gp120 protein and/or antiretroviral drug dideoxycytidine (ddC) and the therapeutic actions of insulin-like growth factor-1 (IGF-1) on gp120- or ddC-induced neurotoxicity. DRG neurons were exposed to gp120 (500 pmol/L), ddC ($50{\mu}mol/L$), gp120 (500 pmol/L) plus ddC ($50{\mu}mol/L$), gp120 (500 pmol/L) plus IGF-1 (20 nmol/L), ddC ($50{\mu}mol/L$) plus IGF-1 (20 nmol/L), gp120 (500 pmol/L) plus ddC ($50{\mu}mol/L$) plus IGF-1 (20 nmol/L), respectively, for 72 hours. The results showed that gp120 and/or ddC caused neurotoxicity of primary cultured DRG neurons. Interestingly, the severity of neurotoxicity induced by gp120 and ddC was different in different subpopulation of DRG neurons. gp120 mainly affected large diameter DRG neurons (> $25{\mu}m$), whereas ddC mainly affected small diameter DRG neurons (${\leq}25{\mu}m$). IGF-1 could reverse the neurotoxicity induced by gp120 and/or ddC on small, but not large, DRG neurons. These data provide new insights in elucidating the pathogenesis of HIV infection- or antiretroviral therapy-related peripheral neuropathy and facilitating the development of novel treatment strategies.
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참고문헌 (31)
참고문헌 신청
Acharjee, S / 2011 / Proteinase-activated receptor-1 mediatesdorsal root ganglion neuronal degeneration in HIV/AIDS / Brain 134:3209~3221
Blackbeard, J / 2012 / Thecorrelation between pain-related behaviour and spinal microgliosisin four distinct models of peripheral neuropathy / Eur. J. Pain 16:1357~1367
Bomze, H. M / 2001 / Spinal axon regeneration evoked by replacing twogrowth cone proteins in adult neurons / Nat. Neurosci 4:38~43
Chirivella, L / 2012 / IRS2signalling is required for the development of a subset of sensoryspinal neurons / Eur. J. Neurosci 35:341~352
Craner, M. J / 2002 / Preferentialexpression of IGF-I in small DRG neurons and down-regulationfollowing injury / Neuroreport 13:1649~1652
Blackbeard, J / 2012 / Thecorrelation between pain-related behaviour and spinal microgliosisin four distinct models of peripheral neuropathy / Eur. J. Pain 16:1357~1367
Bomze, H. M / 2001 / Spinal axon regeneration evoked by replacing twogrowth cone proteins in adult neurons / Nat. Neurosci 4:38~43
Chirivella, L / 2012 / IRS2signalling is required for the development of a subset of sensoryspinal neurons / Eur. J. Neurosci 35:341~352
Craner, M. J / 2002 / Preferentialexpression of IGF-I in small DRG neurons and down-regulationfollowing injury / Neuroreport 13:1649~1652
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