지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 40 - 45 (6page)
이용수
초록· 키워드
오류제보하기
The objective of this study was to investigate the single dose and 2-week repeated dose toxicity of Aceporol 330 in ICR mice following single intravenous administration and to compare its toxicity with a commercially available solubilizer of paclitaxel, Cremophor EL. In single dose toxicity test, $LD_{50}$ of Aceporol 330 in mice was estimated to be greater than maximum applicable dose, 4 ml/kg. However, $LD_{50}$ of Cremophor EL in male mice was determined to be 4 ml/kg. Maximum tolerated dose (MTD) of males and females in Aceporol 330-treated group and MTD of females in Cremophor EL-treated group were 3 ml/kg. MTD of males in Cremophor EL-treated group was less than 3 ml/kg. Characteristic toxic symptoms, and hematological and blood chemical changes were not observed after single dose and repeated dose of Aceporol 330 or Cremophor EL. No histopathological abnormalities were found in organs of all animal groups. Based on the linear pharmacokinetic property of paclitaxel and the higher $LD_{50}$ in mice, Aceporol 330 has a potential for use as a safer solubilizer for paclitaxel than Cremophor EL.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Chalfant, C. E. / 2002 / De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1 / J Biol Chem 277:12587~12595
Chen, J. / 1995 / Regulation of cytochrome P450 2C11(CYP2C11)gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes / J Biol Chem 270:25233~25238
Chun, Y. J. / 2003 / Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells / Toxicol Lett 146:75~81
Cock, J. G. / 1998 / CD95(Fas/APO-1)induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase / J Biol Chem 273:7560~7565
Cuvillier, O. / 2003 / Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer / Pharmacol Res 47:439~445
Chen, J. / 1995 / Regulation of cytochrome P450 2C11(CYP2C11)gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes / J Biol Chem 270:25233~25238
Chun, Y. J. / 2003 / Activation of Fas receptor modulates cytochrome P450 3A4 expression in human colon carcinoma cells / Toxicol Lett 146:75~81
Cock, J. G. / 1998 / CD95(Fas/APO-1)induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase / J Biol Chem 273:7560~7565
Cuvillier, O. / 2003 / Enzymes of sphingosine metabolism as potential pharmacological targets for therapeutic intervention in cancer / Pharmacol Res 47:439~445
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Toxicity of Novel Solubilizer of Paclitaxel, Aceporol 330, in Beagle Dogs
Biomolecules & Therapeutics(구 응용약물학회지)
2008 .01
-
The toxicity of Aceporol 460 as a novel high loading capacity solubilizer of paclitaxel
대한약학회 학술대회
2002 .01
-
Pharmacokinetics of New Solubilizer in Intravenous Micelle Formulation of Paclitaxel in Mice
대한약학회 학술대회
2002 .01
-
Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
대한약학회 학술대회
2002 .01
-
Toxicity test of new solubilizer for paclitaxel in Beagle dog
대한약학회 학술대회
2001 .01
-
The repeated dosing toxicity tests of a novel solubilizer for paclitaxel in male beagle dogs
대한약학회 학술대회
2002 .01
-
The repeated dosing toxicity tests of a novel solubilizer for paclitaxel in male beagle dogs
한국응용약물학회 추계학술발표논문집
2002 .01
-
Pharmacokinetics of new solubilizer in the intravenous micelle formulation of paclitaxel
대한약학회 학술대회
2001 .01
-
Oral Single Dose Toxicity Study of Low Molecular Fucoidan in Mice
Toxicological Research
2008 .03
-
Single and Two-Week Repeated Oral Dose Toxicity Study of DHP2, a Hydrophobic Drug Delivery Vehicle in Mice
Toxicological Research
2004 .03
-
Single and Two-Week Repeated Oral Dose Toxicity Study of DHP2, a Hydrophobic Drug Delivery Vehicle in Mice
Toxicological Research
2004 .06
-
Non-convulsive seizure related to Cremophor EL™-free, polymeric micelle formulation of paclitaxel: a case report
Obstetrics & Gynecology Science
2018 .01
-
Single and 28-day Repeated Dose Toxicity Studies of Botulinum Toxin Type A in Mice and Rats
대한약학회 학술대회
2003 .01
-
Single Oral Dose Toxicity Study of Pinelliae Rhizoma Aqueous Extract in ICR Mice
Toxicological Research
2009 .09
-
補中益氣合大七氣湯 추출물의 ICR 마우스에서 경구 단회투여독성 평가
대한한방내과학회지
2005 .01
-
천연형 인성장호르몬 DA-3002의 단회 및 13주 반복투여독성연구
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
-
Salicornia herbacea evaluate the single dose toxicity in mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
초오약침의 단회 및 4주 반복 투여 독성에 관한 실험적 연구
Korean Journal of Acupuncture
2017 .01
-
Pharmacokinetic behavior of lipid nanodispersion system for parenteral delivery of paclitaxel in rats
대한약학회 학술대회
2003 .01
-
Single Oral Dose Toxicity Test of Persicae Semen Aqueous Extracts in Mice
대한본초학회지(본초분과학회지)
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0