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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 282 - 287 (6page)
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초록· 키워드
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Sirt1, a nicotinamide adenine dinucleotide ($NAD^+$)-dependent histone deacetylase, is known to deacetylate a number of proteins that are involved in various cellular pathways such as the stress response, apoptosis and cell growth. Modulation of the stress response by Sirtuin 1 (Sirt1) is achieved by the deacetylation of key proteins in a cellular pathway, and leads to a delay in the onset of cancer or aging. In particular, Sirt1 is known to play an important role in maintaining genomic stability, which may be strongly associated with a protective effect during tumorigenesis and during the onset of aging. In these studies, Sirt1 was generated in stably expressing cells and during the stimulation of DNA damage to examine whether it promotes survival. Sirt1 expressing cells facilitated the repair of DNA damage induced by either ionizing radiation (IR) or bleomycin (BLM) treatment. Fastened damaged DNA repair in Sirt1 expressing cells corresponded to prompt activation of Chk2 and ${\gamma}$-H2AX foci formation and promoted survival. Inhibition of Sirt1 enzymatic activity by a chemical inhibitor, nicotinamide (NIC), delayed DNA damage repair, indicating that promoted DNA damage repair by Sirt1 functions to induce survival when DNA damage occurs.
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참고문헌 (28)
참고문헌 신청
Bao, S / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444:756~760
Bitterman, K. J / 2002 / Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 / J. Biol. Chem 277:45099~45107
Bradbury, C. A / 2005 / Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors / Leukemia 19:1751~1759
Brooks, C. L / 2009 / How does SIRT1 affect metabolism, senescence and cancer / Nat. Rev. Cancer 9:123~128
Burma, S / 2001 / ATM phosphorylates histone H2AX in response to DNA double-strand breaks / J. Biol. Chem 276:42462~42467
Bitterman, K. J / 2002 / Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 / J. Biol. Chem 277:45099~45107
Bradbury, C. A / 2005 / Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors / Leukemia 19:1751~1759
Brooks, C. L / 2009 / How does SIRT1 affect metabolism, senescence and cancer / Nat. Rev. Cancer 9:123~128
Burma, S / 2001 / ATM phosphorylates histone H2AX in response to DNA double-strand breaks / J. Biol. Chem 276:42462~42467
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