지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 268 - 272 (5page)
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초록· 키워드
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Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly due to the damage or destruction of kidney function by exogenous or endogenous toxicants. Exposure to drugs often results in toxicity in kidney which represents the major control system maintaining homeostasis of body and thus is especially susceptible to xenobiotics. Understanding the toxic mechanisms for nephrotoxicity provides useful information on the development of drugs with therapeutic benefits with reduced side effects. Mechanisms for drug-induced nephrotoxicity include changes in glomerular hemodynamics, tubular cell toxicity, inflammation, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy. Biomarkers have been identified for the assessment of nephrotoxicity. The discovery and development of novel biomarkers that can diagnose kidney damage earlier and more accurately are needed for effective prevention of drug-induced nephrotoxicity. Although some of them fail to confer specificity and sensitivity, several promising candidates of biomarkers were recently proved for assessment of nephrotoxicity. In this review, we summarize mechanisms of drug-induced nephrotoxicity and present the list of drugs that cause nephrotoxicity and biomarkers that can be used for early assessment of nephrotoxicity.
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참고문헌 (57)
참고문헌 신청
Alchi, B. / 2005 / Osteopontin expression in acute renal allograft rejection / Kidney Int 67:886~896
Bailly, V. / 2002 / Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration / J. Biol. Chem 277:39739~39748
Baron, S. / 1991 / The interferons. Mechanisms of action and clinical applications / JAMA 266:1375~1383
Bernard, A. M. / 1987 / Assessment of urinary retinol-binding protein as an index of proximal tubular injury / Clin. Chem 33:775~779
Bonventre, J. V. / 2010 / Next-generation biomarkers for detecting kidney toxicity / Nat. Biotechnol 28:436~440
Bailly, V. / 2002 / Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration / J. Biol. Chem 277:39739~39748
Baron, S. / 1991 / The interferons. Mechanisms of action and clinical applications / JAMA 266:1375~1383
Bernard, A. M. / 1987 / Assessment of urinary retinol-binding protein as an index of proximal tubular injury / Clin. Chem 33:775~779
Bonventre, J. V. / 2010 / Next-generation biomarkers for detecting kidney toxicity / Nat. Biotechnol 28:436~440
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