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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 395 - 403 (9page)
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초록· 키워드
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Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis via oxidative stress, particulate matter 2.5 ($PM_{2.5}$) was shown to trigger excessive production of reactive oxygen species. In this study, we observed that UVB radiation and $PM_{2.5}$ severely damaged human HaCaT keratinocytes, disrupting cellular DNA, lipids, and proteins and causing mitochondrial depolarization. Purpurogallin protected HaCaT cells from apoptosis induced by UVB radiation and/or $PM_{2.5}$. Furthermore, purpurogallin effectively modulates the pro-apoptotic and anti-apoptotic proteins under UVB irradiation via caspase signaling pathways. Additionally, purpurogallin reduced apoptosis via MAPK signaling pathways, as demonstrated using MAPK-p38, ERK, and JNK inhibitors. These results indicate that purpurogallin possesses antioxidant effects and protects cells from damage and apoptosis induced by UVB radiation and $PM_{2.5}$.
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참고문헌 (36)
참고문헌 신청
Agar, N. S / 2004 / The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations : a role for UVA in human skin carcinogenesis / Proc. Natl. Acad. Sci. U. S. A 101:4954~4959
Boakye, C. H. A / 2016 / Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention / Colloids Surf. B Biointerfaces 143:156~167
Brentnall, M / 2013 / Caspase-9, caspase-3 and caspase-7have distinct roles during intrinsic apoptosis / BMC Cell Biol 14:32
Cao, J / 2016 / Overproduction of reactive oxygen species and activation of MAPKs are involved in apoptosis induced by PM2. 5 in rat cardiac H9c2 cells / J. Appl. Toxicol 36:609~617
Castañeda, A. R / 2018 / Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization / Toxicol. Lett 292:85~96
Boakye, C. H. A / 2016 / Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention / Colloids Surf. B Biointerfaces 143:156~167
Brentnall, M / 2013 / Caspase-9, caspase-3 and caspase-7have distinct roles during intrinsic apoptosis / BMC Cell Biol 14:32
Cao, J / 2016 / Overproduction of reactive oxygen species and activation of MAPKs are involved in apoptosis induced by PM2. 5 in rat cardiac H9c2 cells / J. Appl. Toxicol 36:609~617
Castañeda, A. R / 2018 / Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization / Toxicol. Lett 292:85~96
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