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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 225 - 241 (17page)
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초록· 키워드
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Taurine is an abundant, ${\beta}-amino$ acid with diverse cytoprotective activity. In some species, taurine is an essential nutrient but in man it is considered a semi-essential nutrient, although cells lacking taurine show major pathology. These findings have spurred interest in the potential use of taurine as a therapeutic agent. The discovery that taurine is an effective therapy against congestive heart failure led to the study of taurine as a therapeutic agent against other disease conditions. Today, taurine has been approved for the treatment of congestive heart failure in Japan and shows promise in the treatment of several other diseases. The present review summarizes studies supporting a role of taurine in the treatment of diseases of muscle, the central nervous system, and the cardiovascular system. In addition, taurine is extremely effective in the treatment of the mitochondrial disease, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), and offers a new approach for the treatment of metabolic diseases, such as diabetes, and inflammatory diseases, such as arthritis. The review also addresses the functions of taurine (regulation of antioxidation, energy metabolism, gene expression, ER stress, neuromodulation, quality control and calcium homeostasis) underlying these therapeutic actions.
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참고문헌 (188)
참고문헌 신청
Abramov, A. Y. / 2008 / Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity / Biochim. Biophys. Acta 1777:953~964
Abramov, A. Y. / 2007 / Three distinct mechanisms generate oxygen free radicals in neurons and con-tribute to cell death during anoxia and reoxygenation / J. Neurosci. 27:1129~1138
Ahmadian, M. / 2017 / Taurine supplementation improves functional capacity, myocardial oxygen consumption and electrical activity in heart failure / J. Diet. Suppl. 14:422~432
Airaksinen, E. M. / 1980 / Effects of taurine treatment on epileptic patients / Prog. Clin. Biol. 39:157~166
Albrecht, J. / 2005 / Taurine interaction with neurotransmitter receptors in the CNS: an update / Neurochem. Res. 30:1615~1621
Abramov, A. Y. / 2007 / Three distinct mechanisms generate oxygen free radicals in neurons and con-tribute to cell death during anoxia and reoxygenation / J. Neurosci. 27:1129~1138
Ahmadian, M. / 2017 / Taurine supplementation improves functional capacity, myocardial oxygen consumption and electrical activity in heart failure / J. Diet. Suppl. 14:422~432
Airaksinen, E. M. / 1980 / Effects of taurine treatment on epileptic patients / Prog. Clin. Biol. 39:157~166
Albrecht, J. / 2005 / Taurine interaction with neurotransmitter receptors in the CNS: an update / Neurochem. Res. 30:1615~1621
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