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학술저널
저자정보
Neugent, Michael L. (Department of Biological Sciences, The University of Texas at Dallas) Goodwin, Justin (Yale School of Medicine) Sankaranarayanan, Ishwarya (Department of Biological Sciences, The University of Texas at Dallas) Yetkin, Celal Emre (Department of Biological Sciences, The University of Texas at Dallas) Hsieh, Meng-Hsiung (Department of Biological Sciences, The University of Texas at Dallas) Kim, Jung-whan (Department of Biological Sciences, The University of Texas at Dallas)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제26권 제1호
발행연도
2018.1
수록면
10 - 18 (9page)

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Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has emphasized a uniformly elevated aerobic glycolysis as a critical feature of tumorigenecity. This led to extensive efforts of targeting glycolysis in human cancers. However, clinical attempts to target glycolysis and glucose metabolism have proven to be challenging. Recent advancements revealing a high degree of metabolic heterogeneity and plasticity embedded among various human cancers may paint a new picture of metabolic targeting for cancer therapies with a renewed interest in glucose metabolism. In this review, we will discuss diverse oncogenic and molecular alterations that drive distinct and heterogeneous glucose metabolism in cancers. We will also discuss a new perspective on how aberrantly altered glycolysis in response to oncogenic signaling is further influenced and remodeled by dynamic metabolic interaction with surrounding tumor-associated stromal cells.

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