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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 234 - 240 (7page)
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초록· 키워드
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Monoamine oxidase inhibitors (MAOI) have been widely used as antidepressants. Recently, there has been renewed interest in MAO inhibitors. The activity-guided fractionation of extracts from Angelica keiskei Koidzumi (A. keiskei K.) led to the isolation of two prenylated chalcones, xanthoangelol and 4-hydroxyderricin and a flavonoid, cynaroside. These three isolated compounds are the major active ingredients of A. keiskei K. to inhibit the MAOs and DBH activities. Xanthoangelol is a nonselective MAO inhibitor, and a potent dopamine ${\beta}$-hydroxylase (DBH) inhibitor. $IC_{50}$ values of xanthoangelol to MAO-A and MAO-B were calculated to be 43.4 ${\mu}M$, and 43.9 ${\mu}M$. These values were very similar to iproniazid, which is a nonselective MAO inhibitor used as a drug against depression. The $IC_{50}$ values of iproniazid were 37 ${\mu}M$, and 42.5 ${\mu}M$ in our parallel examination. Moreover, $IC_{50}$ value of xanthoangelol to DBH was calculated 0.52 ${\mu}M$. 4-Hydroxyderricin is a potent selective MAO-B inhibitor and also mildly inhibits DBH activity. The $IC_{50}$ value of 4-hydroxyderricin to MAO-B was calculated to be 3.43 ${\mu}M$ and this value was higher than that of deprenyl (0.046 ${\mu}M$) used as a positive control for selective MAO-B inhibitor in our test. Cynaroside is a most potent DBH inhibitor. The $IC_{50}$ value of cynaroside to DBH was calculated at 0.0410 ${\mu}M$. Results of this study suggest that the two prenylated chalcones, xanthoangelol and 4-hydroxyderricin isolated from A. keiskei K., are expected for potent candidates for development of combined antidepressant drug. A. keiskei K. will be an excellent new bio-functional food material that has the combined antidepressant effect.
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참고문헌 (23)
참고문헌 신청
Akihisa, T. / 2003 / Chalcones, coumarins, and fl avanones from the exudate of Angelica keiskei and their chemopreventive effects / Cancer Lett 201:133~137
Baba, K. / 1990 / Chalcones from Angelica keiskei / Phytochemistry 29:3907~3910
Birkmayer, W. / 1983 / (-)-Deprenyl leads to prolongation of L-dopa effi cacy in Parkinson's disease / Mod. Probl. Pharmacopsychiatry 19:170~176
Fujita, T. / 1992 / The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit / Res. Comun. Chem. Pathol. Pharmacol 77:227~240
Han, Y. N. / 2001 / Monoamine oxidase B inhibitors from the fruits of Opuntia fi cus-indica var. saboten / Arch. Pharm. Res 24:51~54
Baba, K. / 1990 / Chalcones from Angelica keiskei / Phytochemistry 29:3907~3910
Birkmayer, W. / 1983 / (-)-Deprenyl leads to prolongation of L-dopa effi cacy in Parkinson's disease / Mod. Probl. Pharmacopsychiatry 19:170~176
Fujita, T. / 1992 / The effects of xanthoangelol E on arachidonic acid metabolism in the gastric antral mucosa and platelet of the rabbit / Res. Comun. Chem. Pathol. Pharmacol 77:227~240
Han, Y. N. / 2001 / Monoamine oxidase B inhibitors from the fruits of Opuntia fi cus-indica var. saboten / Arch. Pharm. Res 24:51~54
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