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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 149 - 155 (7page)
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초록· 키워드
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Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human blood by investigating its ability to inhibit aggregations induced by various agonists in human platelet rich plasma (PRP). This study also investigated the underlying mechanism of yuzu focusing on ADP granule secretion, $TXB_2$ formations, and $PLC{\gamma}$/Akt signaling. The results from this study showed that ethanolic yuzu extract (YE), and its components, hesperidin and naringin, inhibited human platelet aggregation in a concentration-dependent manner. YE, hesperidin and naringin also inhibited $TXB_2$ formation and ADP release. The phosphorylation of $PLC{\gamma}$ and Akt was significantly inhibited by YE, heperidin and naringin. Furthermore, we demonstrated that YE, heperidin and naringin has anti-platelet effects in rat ex vivo studies, and lower side effects in mice tail bleeding time studies. The results from this study suggest that YE, hesperidin and naringin can inhibit human platelet aggregation, at least partly through the inhibition of $PLC{\gamma}$ and Akt, leading to a decrease in $TXB_2$ formation and granule secretion.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Barrett, N. E. / 2008 / Future innovations in anti-platelet therapies / Br. J. Pharmacol 154:918~939
Bassand, J. P. / 2013 / Current antithrombotic agents for acute coronary syndromes: focus on bleeding risk / Int. J. Cardiol 163:5~18
조현정 / 2011 / Spinach Saponin-Enriched Fraction Inhibits Platelet Aggregation in cAMP- and cGMP-Dependent Manner by Decreasing TXA_2 Production and Blood Coagulation / Biomolecules & Therapeutics 19(2):218~223
Cho, J. / 2008 / A critical role for extracellular protein disulfide isomerase during thrombus formation in mice / J. Clin. Invest 118:1123~1131
Endale, M. / 2012 / Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation / Br. J. Pharmacol 167:109~127
Bassand, J. P. / 2013 / Current antithrombotic agents for acute coronary syndromes: focus on bleeding risk / Int. J. Cardiol 163:5~18
조현정 / 2011 / Spinach Saponin-Enriched Fraction Inhibits Platelet Aggregation in cAMP- and cGMP-Dependent Manner by Decreasing TXA_2 Production and Blood Coagulation / Biomolecules & Therapeutics 19(2):218~223
Cho, J. / 2008 / A critical role for extracellular protein disulfide isomerase during thrombus formation in mice / J. Clin. Invest 118:1123~1131
Endale, M. / 2012 / Ginsenoside-Rp1 inhibits platelet activation and thrombus formation via impaired glycoprotein VI signalling pathway, tyrosine phosphorylation and MAPK activation / Br. J. Pharmacol 167:109~127
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