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논문 기본 정보

자료유형
학술저널
저자정보
Chung, Eunkyung (BIO R&D Center, L&K BIOMED CO., LTD.) Yoon, Tae Gyoon (Department of Anesthesiology and Pain Medicine, Konkuk University Medical Center, Research Institute of Medical Science, Konkuk University School of Medicine) Kim, Sumin (Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University) Kang, Moonkyu (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University) Kim, Hyun Jeong (Department of Dental Anesthesiology and Dental Research Institute, School of Dentistry, Seoul National University) Son, Youngsook (Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제25권 제3호
발행연도
2017.1
수록면
259 - 265 (7page)

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This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.
#Mechanical allodynia #GFAP #IL-10 #Neuropathic pain #Substance P #Glial inactivation

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참고문헌 (38)

참고문헌 신청
Andoh, T. / 1998 / Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice / J. Pharmacol. Exp. Ther 286:1140~1145 google schola Austin, P. J. / 2010 / The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines / J. Neuroimmunol 229:26~50 google schola Bradesi, S. / 2010 / Role of spinal cord glia in the central processing of peripheral pain perception / Neurogastroenterol. Motil 22:499~511 google schola Chen, W. L. / 2006 / Neurokinin-1 receptor in peripheral nerve terminals mediates thermal hyperalgesia / Biochem. Biophys. Res. Commun 339:132~136 google schola Dong, X. G. / 2005 / Alterations in the substance P-induced anti-nociception in the central nervous system of rats after morphine tolerance / Neurosci. Lett 381:47~50 google schola

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