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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 233 - 237 (5page)
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초록· 키워드
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Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Shikonin significantly relaxed fluoride-, thromboxane $A_2$- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, shikonin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and the inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of shikonin on agonist-induced vascular contraction regardless of endothelial function.
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참고문헌 (22)
참고문헌 신청
Andujar, I. / 2002 / Pharmacological properties of shikonin-A review of literature since 2002 / Planta Med 79:1685~1697
Chang, I. C. / 2010 / Shikonin induces apoptosis through reactive oxygen species extracellular signal-regulated kinase pathway in osteosarcoma cells / Biol. Pharm. Bull 33:816~824
Chen, X. / 2002 / Cellular pharmacology studies of shikonin derivatives / Phytother. Res 16:199~209
Gu, Z. / 2007 / Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells / Exp. Cell Res 313:849~866
Han, W. / 2007 / Shikonin circumvents cancer drug resistance by induction of a necroptotic death / Mol. Cancer Ther 6:1641~1649
Chang, I. C. / 2010 / Shikonin induces apoptosis through reactive oxygen species extracellular signal-regulated kinase pathway in osteosarcoma cells / Biol. Pharm. Bull 33:816~824
Chen, X. / 2002 / Cellular pharmacology studies of shikonin derivatives / Phytother. Res 16:199~209
Gu, Z. / 2007 / Erk1/2 MAPK and caldesmon differentially regulate podosome dynamics in A7r5 vascular smooth muscle cells / Exp. Cell Res 313:849~866
Han, W. / 2007 / Shikonin circumvents cancer drug resistance by induction of a necroptotic death / Mol. Cancer Ther 6:1641~1649
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