지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 420 - 425 (6page)
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초록· 키워드
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Esophageal reflux of gastric contents causes esophageal mucosal damage and inflammation. Recent studies show that oxygen-derived free radicals mediate mucosal damage in reflux esophagitis (RE). Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is one of the most abundant polyphenols in the human diet and possesses anti-inflammatory, antibacterial and anti-oxidant activities. In this context, we investigated the effects of CGA against experimental RE in rats. RE was produced by ligating the transitional region between the forestomach and the glandular portion and covering the duodenum near the pylorus ring with a small piece of catheter. CGA (10, 30 and 100 mg/kg) and omeprazole (positive control, 10 mg/kg) were administered orally 48 h after the RE operation for 12 days. CGA reduced the severity of esophageal lesions, and this beneficial effect was confirmed by histopathological observations. CGA reduced esophageal lipid peroxidation and increased the reduced glutathione/oxidized glutathione ratio. CGA attenuated increases in the serum level of tumor necrosis factor-${\alpha}$, and expressions of inducible nitric oxide synthase and cyclooxygenase-2 protein. CGA alleviates RE-induced mucosal injury, and this protection is associated with reduced oxidative stress and the anti-inflammatory properties of CGA.
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참고문헌 (37)
참고문헌 신청
Abdel-Latif, M. M / 2009 / Inflammation and esophageal carcinogenesis / Curr. Opin. Pharmacol 9:396~404
Belkaid, A / 2006 / Thechemopreventive properties of chlorogenic acid reveal a potentialnew role for the microsomal glucose-6-phosphate translocase inbrain tumor progression / Cancer Cell Int 6:7
Bredenoord, A. J / 2006 / Determinants of perception of heartburn andregurgitation / Gut 55:313~318
Buege, J. A / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52:302~310
Ji Won Cha / 2014 / The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes / Biomolecules & Therapeutics 22(2):136~142
Belkaid, A / 2006 / Thechemopreventive properties of chlorogenic acid reveal a potentialnew role for the microsomal glucose-6-phosphate translocase inbrain tumor progression / Cancer Cell Int 6:7
Bredenoord, A. J / 2006 / Determinants of perception of heartburn andregurgitation / Gut 55:313~318
Buege, J. A / 1978 / Microsomal lipid peroxidation / Methods Enzymol 52:302~310
Ji Won Cha / 2014 / The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes / Biomolecules & Therapeutics 22(2):136~142
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