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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 355 - 361 (7page)
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Objective : The aim of this study to investigate the normal values of erythropoietin (EPO) and neuroprotective effects of quercetin and mannitol on EPO and hematocrit levels after acute severe traumatic brain injury (TBI) in rat model. Methods : A weight-drop impact acceleration model of TBI was used on 40 male Wistar rats. The animals were divided into sham (group I), TBI (group II), TBI+quercetin (50 mg/kg intravenously) (group III), and TBI+mannitol (1 mg/kg intravenously) (group IV) groups. The malondialdehyde, glutathione peroxidase, catalase, EPO, and hematocrit levels were measured 1 and 4 hour after injury. Two-way repeated measures analysis of variance and Tukey's test were used for statistical analysis. Results : The malondialdehyde levels decreased significantly after administration of quercetin and mannitol compared with those in group II. Catalase and glutathione peroxidase levels increased significantly in groups III and IV. Serum EPO levels decreased significantly after mannitol but not after quercetin administration. Serum hematocrit levels did not change significantly after quercetin and mannitol administration 1 hour after trauma. However, mannitol administration decreased serum hematocrit levels significantly after 4 hour. Conclusion : This study suggests that quercetin may be a good alternative treatment for TBI, as it did not decrease the EPO levels.
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참고문헌 (51)
참고문헌 신청
Akdemir Ozisik P / 2007 / Effect of erythropoietin on brain tissue after experimental head trauma in rats / Surg Neurol 68:547~555
Ansari MA / 2009 / Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease / J Nutr Biochem 20:269~275
Naci Balak / 2009 / Does Serum Osmolarity Change as a Result of the Reflex Neuroprotective Mechanism of Cerebral Osmo-Regulation after Minor Head Trauma? / 대한신경외과학회지 45(3):151~156
Basarslan SK / 2015 / The effects of erythropoietin, dextran and saline on brain edema and lipid peroxidation in experimental head trauma / Ulus Travma Acil Cerrahi Derg 21:235~240
Bischoff SC / 2008 / Quercetin: potentials in the prevention and therapy of disease / Curr Opin Clin Nutr Metab Care 11:733~740
Ansari MA / 2009 / Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease / J Nutr Biochem 20:269~275
Naci Balak / 2009 / Does Serum Osmolarity Change as a Result of the Reflex Neuroprotective Mechanism of Cerebral Osmo-Regulation after Minor Head Trauma? / 대한신경외과학회지 45(3):151~156
Basarslan SK / 2015 / The effects of erythropoietin, dextran and saline on brain edema and lipid peroxidation in experimental head trauma / Ulus Travma Acil Cerrahi Derg 21:235~240
Bischoff SC / 2008 / Quercetin: potentials in the prevention and therapy of disease / Curr Opin Clin Nutr Metab Care 11:733~740
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