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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 273 - 279 (7page)
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Hesperidin, a flavanone present in citrus fruits, has been studied as potential therapeutic agents that have anti-tumor activity and apoptotic effects in several cancers, but there is no report about the apoptotic effect of hesperidin in human malignant pleural mesothelioma through the specificity protein 1 (Sp1) protein. We investigated whether hesperidin inhibited cell growth and regulated Sp1 target proteins by suppressing the levels of Sp1 protein in MSTO-211H cells. The $IC_{50}$ value of hesperidin was determined to be 152.3 ${\mu}M$ in MSTO-211H cells for 48 h. Our results suggested that hesperidin (0-160 ${\mu}M$) decreased cell viability, and induced apoptotic cell death. Hesperidin increased Sub-$G_1$ population in MSTO-211H cells. Hesperidin significantly suppressed mRNA/protein level of Sp1 and modulated the expression level of the Sp1 regulatory protein such as p27, p21, cyclin D1, Mcl-1, and survivin in mesothelioma cells. Also, hesperidin induced apoptotic signaling including: cleavages of Bid, caspase-3, and PARP, upregulation of Bax, and down-regulation of Bcl-$_{xl}$ in mesothelioma cells. These results show that hesperidin suppressed mesothelioma cell growth through inhibition of Sp1. In this study, we demonstrated that Sp1 acts as a novel molecular target of hesperidin in human malignant pleural mesothelioma.
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참고문헌 (40)
참고문헌 신청
Akiyama, S. / 2010 / Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats / J. Clin. Biochem. Nutr 46:87~92
Ameer, B. / 1996 / Flavanone absorption after naringin, hesperidin, and citrus administration / Clin. Pharmacol. Ther 60:34~40
Carbone, M. / 2002 / The pathogenesis of mesothelioma / Semin. Oncol 29:2~17
Choi, E. J. / 2007 / Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21 / Nutr. Cancer 59:115~119
Chuang, J. Y. / 2009 / Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells / Int. J. Cancer 125:2066~2076
Ameer, B. / 1996 / Flavanone absorption after naringin, hesperidin, and citrus administration / Clin. Pharmacol. Ther 60:34~40
Carbone, M. / 2002 / The pathogenesis of mesothelioma / Semin. Oncol 29:2~17
Choi, E. J. / 2007 / Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21 / Nutr. Cancer 59:115~119
Chuang, J. Y. / 2009 / Overexpression of Sp1 leads to p53-dependent apoptosis in cancer cells / Int. J. Cancer 125:2066~2076
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