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논문 기본 정보

자료유형
학술저널
저자정보
Kang, Gyeoung-Jin (Department of Pharmacology, School of Medicine, Jeju National University) Han, Sang-Chul (Department of Pharmacology, School of Medicine, Jeju National University) Ock, Jong-Woo (School of Medicine, Jeju National University) Kang, Hee-Kyoung (Department of Pharmacology, School of Medicine, Jeju National University) Yoo, Eun-Sook (Department of Pharmacology, School of Medicine, Jeju National University)
저널정보
한국응용약물학회 Biomolecules & Therapeutics(구 응용약물학회지) Biomolecules & therapeutics 제21권 제2호
발행연도
2013.1
수록면
138 - 145 (8page)

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Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than mature. Chemokines are significant mediators for cell migration, while thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well known as the typical inflammatory chemokines in atopic dermatitis (AD), a pruritic and chronic inflammatory skin disease. We reported recently that the EtOH extract of immature Citrus unshiu inhibits TARC and MDC production. Therefore, we investigated the activity of flavonoids contained in immature Citrus on TARC and MDC levels. As a result, among the various flavonoids, quercetagetin has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids. Quercetagetin particularly has better activity on TARC and MDC level than quercetin. In HPLC analysis, the standard peak of quercetagetin matches the peaks of extract of immature C. unshiu. This suggests that quercetagetin is an anti-inflammatory component in immature C. unshiu.

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