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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 275 - 280 (6page)
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초록· 키워드
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Scutellariae radix, the root of Scutellaria baicalensis, is a traditional medicinal herb containing baicalin and wogonoside as the main flavonoids. Before absorption, these flavonoids are metabolized into their corresponding aglycones, baicalein and wogonin, by ${\beta}$-glucuronidase produced by the intestinal microflora. To develop a method for efficient transformation of these flavonoids, optimal conditions for the production of ${\beta}$-glucuronidase from Lactobacillus delbrueckii Rh2 (Rh2) were determined. Addition of 4% galactose to basal medium increased the enzyme activity of Rh2 by about 8-fold. Optimal pH and temperature for the ${\beta}$-glucuronidase activity of cell extract were 5.0 and $50^{\circ}C$, respectively, and more than 95% of the enzyme activity was maintained at $60^{\circ}C$ for 11 h. Under optimal conditions, more than 90% of the glycones were converted into their corresponding aglycones within 3 h. These results demonstrate that the transformation of baicalin and wogonoside from S. baicalensis by Rh2 would be useful for the efficient production of wogonin and baicalein.
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