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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 112 - 119 (8page)
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초록· 키워드
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Compounds from Lingzhi has been demonstrated the ability for inhibiting tyrosinase (a key enzyme in melanogenesis) activity. In this study, we investigated the anti-melanogenic activity from the submerged mycelial culture of Ganoderma weberianum and elucidated the skin lightening mechanism by B16-F10 murine melanoma cells. From the cellular context, several fractionated mycelium samples exhibited anti-melanogenic activity by reducing more than 40% extracellular melanin content of B16-F10 melanoma cells. In particular, the fractionated chloroform extract (CF-F3) inhibited both secreted and intracellular melanin with the lowest dosage (25 ppm). Further analysis demonstrated that CF-F3 inhibited cellular tyrosinase activity without altering its protein expression. Taken together, our study has demonstrated that the chemical extracts from submerged mycelial culture of G. weberianum have the potential to serve as an alternative anti-melanogenic agent.
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참고문헌 (27)
참고문헌 신청
D’Mello S / 2016 / Signaling pathways in melanogenesis / Int J Mol Sci 17:1144
Lee CS / 2013 / Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation / J Invest Dermatol 133:1063~1071
Kwangmi Kim / 2015 / Effect of ginseng and ginsenosides on melanogenesis and their mechanism of action / Journal of Ginseng Research 39(1):1~6
Weiner L / 2014 / Skin as a living coloring book : how epithelial cells create patterns of pigmentation / Pigment Cell Melanoma Res 27:1014~1031
Chung KW / 2018 / Evaluation of antimelanogenic activity and mechanism of galangin in silico and in vivo / Biol Pharm Bull 41:73~79
Lee CS / 2013 / Liver X receptor activation inhibits melanogenesis through the acceleration of ERK-mediated MITF degradation / J Invest Dermatol 133:1063~1071
Kwangmi Kim / 2015 / Effect of ginseng and ginsenosides on melanogenesis and their mechanism of action / Journal of Ginseng Research 39(1):1~6
Weiner L / 2014 / Skin as a living coloring book : how epithelial cells create patterns of pigmentation / Pigment Cell Melanoma Res 27:1014~1031
Chung KW / 2018 / Evaluation of antimelanogenic activity and mechanism of galangin in silico and in vivo / Biol Pharm Bull 41:73~79
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