Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats

Choi, Won-Sik; Kim, Young-Sun; Park, Byeoung-Soo; Kim, Jang-Eok; Lee, Sung-Eun

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자료유형: 학술저널

저자정보: Choi, Won-Sik (Department of Biotechnology, Soonchunhyang University) Kim, Young-Sun (Department of Biotechnology, Soonchunhyang University) Park, Byeoung-Soo (Research Station, Nanotoxtech Inc.) Kim, Jang-Eok (School of Applied Biosciences, Kyungpook National University) Lee, Sung-Eun (School of Applied Biosciences, Kyungpook National University)

저널정보: 한국균학회 Mycobiology Mycobiology 제41권 제2호

발행연도: 2013.1

수록면: 94 - 99 (6page)

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In this study, ethanolic extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) were assessed for their ability to lower the cholesterol levels of male Sprague-Dawley rats fed a high-fat diet. Rats were randomly subdivided into seven test groups. Each group contained eight rats fed a high-fat diet during a growth period lasting 4 wk. Supplementation with the extracts was performed once a day for 2 wk after the high-fat diet. The control group (rats fed a high-fat diet) showed a high efficiency ratio (feed efficiency ratio) value compared to the normal group. Biochemical parameters, including total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and triglyceride (TG) levels dramatically increased in the control group compared to the normal group. High-density lipoprotein-cholesterol (HDL-c) content in the control group was also significantly lower relative to the normal group. Two positive control groups, treated with simvastatin and atorvastatin, had lowered TC, LDL-c, and TG levels, and increased HDL-c content compared to the control group. Treatment with the tested extracts, including HEAC, ethanolic extracts from Hericium erinaceum, and ethanolic extracts from Artemisia capillaris reduced TC, LDL-c, and TG levels and elevated HDL-c content in the hyperlipidemia rats. The atherogenic index and cardiac risk factor values for the HEAC-treated group were 0.95 and 1.95, respectively. Simvastatin- and atorvastatin-treated groups showed atherogenic index values of 1.56 and 1.69, respectively, and cardiac risk factor values of 2.56 and 2.69, respectively. These results show HEAC possesses an ability to cure hyperlipidemia in rats and may serve as an effective natural medicine for treating hyperlipidemia in humans.

#Atorvastatin #Hericium erinaceum #Hyperlipidemia #Simvastatin

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