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자료유형
학술저널
저자정보
Feng, Jiao (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) Chen, Zhiwen (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) He, Liya (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) Xiao, Xing (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) Chen, Chunmei (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) Chu, Jieming (Johns Hopkins University Bloomberg School of Public Health) Mylonakis, Eleftherios (Division of Infectious Diseases, Rhode Island Hospital, Warren Alpert Medical School of Brown University) Xi, Liyan (Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University)
저널정보
한국균학회 Mycobiology Mycobiology 제47권 제2호
발행연도
2019.1
수록면
207 - 216 (10page)

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Talaromyces marneffei is the only dimorphic species in its genus and causes a fatal systemic mycosis named talaromycosis. Our previous study indicated that knockdown of AcuD gene (encodes isocitrate lyase of glyoxylate bypass) of T. marneffei by RNA interference approach attenuated the virulence of T. marneffei, while the virulence of the AcuD knockout strains was not studied. In this study, T. marneffei-zebrafish infection model was successfully established through hindbrain microinjection with different amounts of T. marneffei yeast cells. After co-incubated at $28^{\circ}C$, the increasing T. marneffei inoculum doses result in greater larval mortality; and hyphae generation might be one virulence factor involved in T. marneffei-zebrafish infection. Moreover, the results demonstrated that the virulence of the ${\Delta}AcuD$ was significantly attenuated in this Zebrafish infection model.

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