지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Patients with neurofibromatosis 1 (NF1) are predisposed to develop central nervous system tumors, due to the loss of neurofibromin, an inactivator of proto-oncogene Ras. However, to our knowledge, only three cases of ependymomas with NF1 have been reported in the literature. The authors present a case of NF1 patient with a spinal cord ependymoma. She was referred for about half a year history of increasing numbness that progressed from her fingers to her entire body above the bellybutton. Magnetic resonance imaging revealed a relative-demarcated, heterogeneously enhanced mass lesion accompanied by perifocal edema in C5-7 level, a left-sided T11 spinous process heterogeneously enhanced mass in soft tissue, intervertebral disk hernia in L2-5 level, and widespread punctum enhancing lesion in her scalp and in T11-L5 level. The patient underwent C5-7 laminectomies and total excision of the tumor under operative microscope, and intraoperative ultrasonography and physiological monitoring were used during the surgery. Histopathologically, her tumor was found to be a ependymoma without malignant features (grade II in the World Health Organization classification). Therefore, no adjuvant therapy was applied. Following the operation, the patient showed an uneventful clinical recovery with no evidence of tumor recurrence after one year of follow-up.
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참고문헌 (26)
참고문헌 신청
Abbott R / 2009 / The use of physiological mapping and monitoring during surgery for ependymomas / Childs Nerv Syst 25:1241~1247
Aguilera DG / 2011 / Neurofibromatosis-2 and spinal cord ependymomas :report of two cases and review of the literature / Childs Nerv Syst 27:757~764
Alkhani A / 2008 / Outcome of surgery for intramedullary spinal ependymoma / Ann Saudi Med 28:109~113
Brems H / 2009 / Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1 / Lancet Oncol 10:508~515
Cnossen MH / 1997 / Deletions spanning the neurofibromatosis type 1 gene : implications for genotype-phenotype correlations in neurofibromatosis type 1? / Hum Mutat 9:458~464
Aguilera DG / 2011 / Neurofibromatosis-2 and spinal cord ependymomas :report of two cases and review of the literature / Childs Nerv Syst 27:757~764
Alkhani A / 2008 / Outcome of surgery for intramedullary spinal ependymoma / Ann Saudi Med 28:109~113
Brems H / 2009 / Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1 / Lancet Oncol 10:508~515
Cnossen MH / 1997 / Deletions spanning the neurofibromatosis type 1 gene : implications for genotype-phenotype correlations in neurofibromatosis type 1? / Hum Mutat 9:458~464
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