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논문 기본 정보

자료유형
학술저널
저자정보
Fraum, Tyler J. (Mallinckrodt Institute of Radiology, Washington University School of Medicine) Fowler, Kathryn J. (Mallinckrodt Institute of Radiology, Washington University School of Medicine) McConathy, Jonathan (Mallinckrodt Institute of Radiology, Washington University School of Medicine)
저널정보
대한핵의학회 Nuclear medicine and molecular imaging : NMMI Nuclear medicine and molecular imaging : NMMI 제50권 제3호
발행연도
2016.1
수록면
228 - 239 (12page)

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Background Because standard MRI-based attenuation correction (AC) does not account for the attenuation of photons by cortical bone, PET/MRI may have reduced sensitivity for FDG-avid focal bone lesions (FFBLs). This study evaluates whether MRI-based AC compromises detection of FFBLs, by comparing their conspicuity both quantitatively and qualitatively on PET/MRI versus PET/CT. Methods One hundred ninety general oncology patients underwent whole-body PET/CT followed by whole-body PET/MRI, utilizing the same FDG dose. Thirteen patients with a total of 50 FFBLs were identified. Using automated contouring software, a volumetric contour was generated for each FFBL. Adjacent regions of normal background bone (BB) were selected manually. For each contour, SUV-max and SUV-mean were determined. Lesion-to-background SUV ratios served as quantitative metrics of conspicuity. Additionally, two blinded readers evaluated the relative conspicuity of FFBLs on PET images derived from MRI-based AC versus CT-based AC. Visibility of an anatomic correlate for FFBLs on the corresponding CT and MR images was also assessed. Results SUV-mean was lower on PET/MRI for both FFBLs (-6.5 %, p = 0.009) and BB (-20.5 %, p< 0.001). SUV-max was lower on PET/MRI for BB (-14.2 %, p = 0.002) but not for FFBLs (-6.2 %, p = 0.068). The ratio of FFBL SUV-mean to BB SUV-mean was higher for PET/MRI (+29.5 %, p < 0.001). Forty of 50 lesions (80 %) were visually deemed to be of equal or greater conspicuity on PET images derived from PET/MRI. Thirty-five of 50 FFBLs (70 %) had CT correlates, while 40/50 FFBLs (80 %) had a correlate on at least one MRI sequence. The mean interval from tracer administration to imaging was longer (p< 0.001) for PET/MRI (127 v. 62 min). Conclusions Both FFBLs and BB had lower mean SUVs on PET/MRI than PET/CT. This finding was likely in part due to differences in the handling of cortical bone by MRI-based AC versus CT-based AC. Despite this systematic bias, FFBLs had greater conspicuity on PET/MRI, both qualitatively and quantitatively. This difference was likely due to the longer tracer uptake times for PET/MRI, which allowed for more tracer accumulation by FFBLs and more tracer washout from BB. Our results suggest that whole-body PET/MRI and PET/CT provide comparable sensitivity for detection of FDG-avid focal bone lesions.
#Clinical oncology #Magnetic resonance imaging #Multimodal imaging #Positron emission tomography #Whole-body imaging

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참고문헌 (21)

참고문헌 신청
Kanda T / 2013 / Value of retrospective image fusion of 18F-FDG PETandMRI for preoperative staging of head and neck cancer : comparison with PET/CT and contrast-enhanced neck MRI / Eur J Radiol 82:2005~2010 google schola Plathow C / 2008 / Positron emission tomography/computed tomography and whole-body magnetic resonance imaging in staging of advanced nonsmall cell lung cancer–initial results / Investig Radiol 43:290~297 google schola Kitajima K / 2014 / Fusion of PETand MRI for staging of uterine cervical cancer : comparison with contrast-enhanced(18)F-FDG PET/CTand pelvic MRI / Clin Imaging 38:464~469 google schola Kitajima K / 2013 / Value of fusion of PET and MRI for staging of endometrial cancer : comparison with 18F-FDG contrast-enhanced PET/CT and dynamic contrast-enhanced pelvic MRI / Eur J Radiol 82:1672~1676 google schola Mundy GR / 2002 / Metastasis to bone : causes, consequences and therapeutic opportunities / Nat Rev Cancer 2:584~593 google schola

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