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논문 기본 정보

자료유형
학술저널
저자정보
Pereira, Nigel (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center) Petrini, Allison C. (Department of Obstetrics and Gynecology, Weill Cornell Medical College) Zhou, Zhen N. (Department of Obstetrics and Gynecology, Weill Cornell Medical College) Lekovich, Jovana P. (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center) Kligman, Isaac (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center) Rosenwaks, Zev (Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical Center)
저널정보
대한생식의학회 Clinical and experimental reproductive medicine : CERM Clinical and experimental reproductive medicine : CERM 제43권 제4호
발행연도
2016.1
수록면
228 - 232 (5page)

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Objective: The aim of this study was to investigate the impact of pretreatment with transdermal estradiol ($E_2$) compared to oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh in vitro fertilization (IVF)-embryo transfer (ET) cycles. Methods: A retrospective cohort study was performed of normal responders undergoing fresh IVF-ET cycles who received pretreatment with transdermal $E_2$ versus OCPs prior to fresh IVF-ET. The total days of ovarian stimulation, total dosage of gonadotropins, total number of oocytes, and mature oocytes retrieved were noted. Pregnancy outcomes after ET were also recorded. Results: A total of 2,092 patients met the inclusion criteria: 1,057 and 1,035 patients in the transdermal $E_2$ and OCP groups, respectively. Patients in the OCP group had a longer duration of COS ($10.7{\pm}1.63days$, p< 0.01) than the $E_2$ group ($9.92{\pm}1.94days$). Patients in the OCP group also required higher cumulative doses of gonadotropins ($2,657.3{\pm}1,187.9IU$) than those in the $E_2$ group ($2,550.1{\pm}1,270.2IU$, p= 0.002). No statistically significant differences were found in the total and mature oocytes retrieved or in the rates of biochemical pregnancy, clinical pregnancy, spontaneous miscarriage, and live birth between the groups. Conclusion: Our findings suggest that compared to OCPs, pretreatment with transdermal $E_2$ is associated with a shorter duration of ovarian stimulation and lower gonadotropin utilization, without compromising the oocyte yield or pregnancy outcomes in normal-responder patients undergoing fresh IVF.

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